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1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Struktur
241127-58-2
CAS-Nr.
241127-58-2
Englisch Name:
1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
Synonyma:
Adaphostin;1-Adamantyl 4-((2;5-Dihydroxybenzyl)Amino)Benzoate;1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate;1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate;4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester;Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester;Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML
CBNumber:
CB41456086
Summenformel:
C24H27NO4
Molgewicht:
393.48
MOL-Datei:
241127-58-2.mol

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Eigenschaften

storage temp. 
Desiccate at +4°C
L?slichkeit
DMSO: soluble20mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

WGK Germany  3

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Novel antitumor agent that induces apoptosis in tumor cells through inhibition of the tyrosine kinase BCR/ABL.

Biologische Aktivit?t

p210 bcr/abl tyrosine kinase inhibitor (IC 50 = 14 μ M). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC 50 values range from 16.8 to 216.3 nM) in vitro . Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro .

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 43)Lieferanten
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15402 60
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
  • 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate
  • 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester
  • Adaphostin
  • 5-Dihydroxybenzyl)Amino)Benzoate
  • 1-Adamantyl 4-((2
  • Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester
  • 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate
  • Apoptosis,tyrosine kinase,inhibit,Bcr-Abl,Adaphostin,chronic myelogenous leukemia,myeloid,Inhibitor,ROS,NSC-680410,p210Bcr/abl,NSC680410,CML
  • 241127-58-2
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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