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Betadex Sulfobutyl Ether Sodium

Betadex Sulfobutyl Ether Sodium Struktur
182410-00-0
CAS-Nr.
182410-00-0
Englisch Name:
Betadex Sulfobutyl Ether Sodium
Synonyma:
SBE-β-CD;CAPTISOL;sodiuM salts;Sulfobutylether-β-Cyclodextrin;b-Cyclodextrin sulfobutyl ether sodium salt;β-Cyclodextrin, sulfobutyl ethers, sodium salts;SBEBCD;Sulfobutyl beta cyclodextrin;sulfobutyl ether B-cyclodextrin;Sulfobutyl Ether-beta-cyclodextrin Sodium Salt
CBNumber:
CB41208906
Summenformel:
C42H70O35
Molgewicht:
1134.9842
MOL-Datei:
182410-00-0.mol

Betadex Sulfobutyl Ether Sodium Eigenschaften

Schmelzpunkt:
202-204°C (dec.)
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
Soluble in water. Insoluble in acetone, methanol, chloroform.
Aggregatzustand
Solid powder
Farbe
White to off white
InChIKey
WHGYBXFWUBPSRW-CQFZCEJCNA-N
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2940006000
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P272 Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P321 Besondere Behandlung
P333+P313 Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P363 Kontaminierte Kleidung vor erneutem Tragen waschen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Betadex Sulfobutyl Ether Sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

β-Cyclodextrin, sulfobutyl ethers, sodium salts is a cyclic oligosaccharide containing seven D-(t)- glucopyranose units attached by α(1→4) glucoside bonds. Sulfobutylether b-cyclodextrin is an anionic bcyclodextrin derivative with a sodium sulfonate salt separated from the hydrophobic cavity by a butyl spacer group. The substituent is introduced at positions 2, 3, and 6 in at least one of the glucopyranose units in the cyclodextrin structure. Introducing the sulfobutylether (SBE) into b-cyclodextrin can produce materials with different degrees of substitution, theoretically from 1 to 21; the hepta-substituted preparation (SBE7-b-CD) is the cyclodextrin with the most desirable drug carrier properties. Sulfobutylether b-cyclodextrin occurs as a white amorphous powder.

Vorbereitung Methode

Sulfobutylether β-cyclodextrin is prepared by alkylation of bcyclodextrin using 1,4-butane sultone under basic conditions. The degree of substitution in b-cyclodextrin is controlled by the stoichiometric ratio of β-cyclodextrin to sultone used in the process.

Toxicity evaluation

Sulfobutylether b-cyclodextrin sodium (SBECD) has been associated with toxic effects in the kidney. Doses up to 1500 mg/kg produced no histopathological evidence of toxicity in dog kidneys.

Sicherheit(Safety)

Sulfobutylether b-cyclodextrin is derived from b-cyclodextrin, which is nephrotoxic when administered parenterally. However, studies have shown that sulfobutylether bcyclodextrin is well tolerated at high doses, when administered via intravenous bolus injections, orally, and by inhalation. Up to 9 g/day may be administered by IV infusion in a licensed voriconazole formulation. The safety following high doses of sulfobutylether β-cyclodextrin intravenous administration in humans is continually being investigated.
Sulfobutylether β-cyclodextrin has been subjected to an extensive battery of in vitro and in vivo genotoxicity and pharmacological evaluations. No genotoxic or mutagenic changes were observed with sulfobutylether β-cyclodextrin administration. Sulfobutylether β-cyclodextrin is biocompatible and exhibits no pharmacological activity. It is rapidly eliminated unmetabolized when administered intravenously.

Lager

Sulfobutylether b-cyclodextrin(182410-00-0) is stable in the solid state and should be protected from high humidity. It should be stored in a tightly sealed container in a cool, dry place.
It will reversibly take up moisture without any effect on the appearance of the material at humidities up to 60% RH. Equilibration at RH values above 60% will result in deliquescence. Once in this state, the material can be dried, but will give a glasslike product. This water absorption behavior is typical of amorphous hygroscopic materials.
Sulfobutylether b-cyclodextrin is stable in aqueous solutions at values above about pH 1. It can degrade in highly acidic (pH < 1) solutions, particularly at elevated temperatures, producing the ring-opened form, followed by hydrolysis of the a(1-4) glucoside bonds.
Sulfobutylether b-cyclodextrin solutions may be autoclaved.

Inkompatibilit?ten

The preservative activity of benzalkonium chloride is reduced in the presence of sulfobutylether b-cyclodextrin.

Regulatory Status

Sulfobutylether β-cyclodextrin is included in IV and IM injectable products currently approved and marketed in the USA, Europe, and Japan. It is included in the FDA Inactive Ingredients Database for IM and IV use. Its use by other routes, including SC, oral, inhalation, nasal and ophthalmic, is being evaluated in clinical studies.

Betadex Sulfobutyl Ether Sodium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Betadex Sulfobutyl Ether Sodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 381)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zibo Wei Bin Import & Export Trade Co. Ltd.
+86-0533-2091136 +8613864437655
ziboweibinmaoyi@163.com China 100 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
Shandong Deshang Chemical Co., Ltd.
+86-0531-8875-2665 +8613153039501
info@deshangchem.com China 662 58
Dalian Richfortune Chemicals Co., Ltd
0411-84820922 8613904096939
sales@richfortunechem.com China 304 57
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075
jack.li@time-chemicals.com China 1803 55

182410-00-0()Verwandte Suche:


  • .beta.-Cyclodextrin, sulfobutyl ethers, sodium salts
  • Sodium sulfobutylether β-cyclodextrin
  • Betadex Sulfobutyl Ether Sodium (500 mg)
  • sulfobutyl ethers
  • SodiuM Sulphobutylether-β-Cyclodextrin
  • CAPTISOL,BETA-CYCLODEXTRIN SULFOBUTYL ETHERS, SODIUM SALT
  • Beta-cyclodextrin Sulfobutyl Ether SodiuM
  • β-Cyclodextrin Sulfobutyl Ethers, Sodium Salts
  • Betadex Sulfobutyl Ether SodiuM
  • Sulfobutyl b-cyclodextrin, sodiuM salt
  • b-Cyclodextrin, sulfobutyl ethers,sodiuM salts
  • Captisol( beta-Cyclodextrin, sulfobutyl ethers, sodium salts)
  • SBE-(beta)-CD
  • Sulfobutyl -β- cyclodextrin sodium
  • Sulfobutyl Ether-β-Cyclodextrin sodium salt
  • Sulfobutyl Ether-β-Cyclodextrin Sodium salt(SBE-β-CD)
  • SBE-β-CD(Sulfobutyl Ether-β-cyclodextrin Sodium salt)
  • BETADEX SULFOBUTYL ETHER SOIDUM
  • sulfobutyl ether sodium salt
  • betadex sulfobuytl ether sodium
  • β-Cyclodextrin, sulfobutyl ethers
  • Sulfobutylated beta-cyclodextrin sodium salt (DS~4)
  • Sulfobutylated beta-cyclodextrin sodium salt (DS~6)
  • Sulfobutylated beta-cyclodextrin sodium salt (DS~10)
  • Sulphobutylether β-cyclodextrin sodium
  • b-Cyclodextrin sulfobutyl ether sodium salt - USP
  • Sodium salt of butyl ether - β - cyclodextrin
  • Sulfonated butyl - beta - cyclodextrin
  • injection grade betadex sulfobutyl ether sodium
  • injection grade sulfobutyl ether-B-cyclodextrin sodium salt
  • injection grade sulfobutyl ether-beta-cyclodextrin sodium salt
  • injection grade sulfobutyl ether-β-cyclodextrin sodium salt
  • sulfobutyl ether-B-cyclodextrin sodium salt
  • BETADEX SULFOBUTYL ETHER BAIK DAN BARU
  • Sulfobutyl Ether beta cyclodextrin Sodium salt Betadex sulfobutyl ether sodium
  • Betadex Sulfobutyl Ether Sodium, NF
  • Sulfobutyl ether-beta-cyclodextrin sodium
  • CAPTISOL & CyDex
  • Captisol(SBE-β-CD)
  • Sulfobutyl - β - cyclodextrin
  • Sulfobutyl ether beta-cyclodextrine sodium
  • Sulfobutyl betacyclodextrin sodium
  • SBE-β-CD (captisol)
  • --Cyclodextrin Sulfobutyl Ethers, Sodium Salts
  • Sulfobutyl -β- cyclodextrin sodium
  • CAPTISOL
  • sodiuM salts
  • SBE-β-CD
  • b-Cyclodextrin sulfobutyl ether sodium salt
  • SBEBCD
  • Sulfobutyl Ether-beta-cyclodextrin Sodium Salt
  • Sulfobutylether-β-Cyclodextrin
  • β-Cyclodextrin, sulfobutyl ethers, sodium salts
  • Sulfobutyl beta cyclodextrin
  • Sodium Sulfobutylether β-Cyclodextrin
  • Sodium sulphobutylether-β-cyclodextrin
  • Sulfobutyl ether Beta Cycledextrin Sodium
  • Sulfobutylether-β-Cyclodextrin/Captisol
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