Meticillin
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- CAS-Nr.
- 61-32-5
- Bezeichnung:
- Meticillin
- Englisch Name:
- methicillin
- Synonyma:
- Metin;C07177;BRL-1241;Metacillin;Dimocillin;Methcilline;methicillin;Dimethoxyphenyl Penicillin;MRSA Selective Supplement;2,6-Dimethoxyphenylpenicillin
- CBNumber:
- CB3889080
- Summenformel:
- C17H20N2O6S
- Molgewicht:
- 380.42
- MOL-Datei:
- 61-32-5.mol
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Meticillin Eigenschaften
- Siedepunkt:
- 640.0±55.0 °C(Predicted)
- Dichte
- 1.44±0.1 g/cm3(Predicted)
- pka
- pKa 2.77± 0.04(H2O,t = 25,c=0.0097) (Uncertain)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Meticillin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
Verwenden
Antibacterial.
Definition
ChEBI: A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.
Antimicrobial activity
2,6-Dimethoxyphenylpenicillin; methicillin (international
non-proprietary name). The first β-lactamase-resistant semisynthetic
penicillin. It was initially used widely but has been
superseded by other group 3 members and is no longer commercially
available.
It is less active than benzylpenicillin or other group 3
penicillins. It is very stable to staphylococcal
β-lactamase and is active against β-lactamaseproducing
strains of Staph. aureus that do not produce a
functional PBP 2a. Resistance is common among
staphylococci, with the incidence geographically diverse.
Most methicillin-resistant staphylococcal isolates display
multiresistance.
It is not acid resistant, and must therefore be administered
parenterally. About 10% is metabolized, with 60–80% of the
dose excreted in the urine. Toxicity is similar to that of other
group 3 penicillins. Nephritis appears to be more common
than with other penicillins.
Pharmakologie
Like other semisynthetic penicillins, methicillin exhibits an antibacterial effect similar to that
of benzylpenicillin. The main difference between methicillin and benzylpenicillin is that it is
not inactivated by the enzyme penicillinase, and therefore it is effective with respect to agents
producing this enzyme (staphylococci). It is used for infections caused by benzylpenicillinresistant staphylococci (septicemia, pneumonia, empyemia, osteomyelitis, abscesses, infected
wounds, and others). Synonyms of this drug are cinopenil, celbenin, staphcillin, and others.
Meticillin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Meticillin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 12)Lieferanten
61-32-5(Meticillin)Verwandte Suche:
- methicillin
- Methcilline
- 2,6-Dimethoxyphenyl-penicillin, Methicillin Selective Supplement, Methicillin, Staphcillin
- MRSA Selective Supplement
- (2S,5R,6R)-6-(2,6-Dimethoxybenzoylamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylic acid
- 2,6-Dimethoxyphenylpenicillin
- BRL-1241
- Dimocillin
- Metacillin
- C07177
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[(2,6-diMethoxybenzoyl)aMino]-3,3-diMethyl-7-oxo-, (2S,5R,6R)-
- Dimethoxyphenyl Penicillin
- Metin
- 61-32-5
