(S,R,S)-AHPC-6-2-2-6-N3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block (S,R,S)-AHPC-C₆-PEG₃-butyl azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

(S,R,S)-AHPC-6-2-2-6-N3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(S,R,S)-AHPC-6-2-2-6-N3 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4825	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1460	58
Zhengzhou convergence chemical co., LTD	0371-0371-55153829 18003835034	2853979819@qq.com	China	9732	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18478	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054 13417589054	trendseenbio@gmail.com	China	9470	58

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• (S,R,S)-AHPC-6-2-2-6-N3
• (2S,4R)-1-((S)-22-Azido-2-(tert-butyl)-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, AHPC-6-2-2-6-N3, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
• (S,R,S)-AHPC-C?-PEG?-butyl azide
• (S,R,S)-AHPC-C6-PEG3-butyl-N3
• (2S,4R)-1-[(2S)-2-[6-(2-{2-[(6-azidohexyl)oxy]ethoxy}ethoxy)hexanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
• 2300155-90-0