3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is an extracellular signal-regulated kinase (ERK) docking domain inhibitor. ERK inhibitors have been used to study traumatic brain injuries.

Biochem/physiol Actions

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC50 = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2.

3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Haoran Biotechnology Co., Ltd.	--	470003480@QQ.COM	CHINA	6955	58
Shanghai Yaoyun Biological Technology Co., Ltd.	--	912529879@qq.com	CHINA	6835	58
Absin Bioscience Inc.	--	chenjw@absin.cn	CHINA	6654	58
Shanghai Weiwei Biological Technology Co., Ltd.	--	sales@wheybio.com	CHINA	4398	58
Morning Student Science and Technology (Guangzhou) Co., Ltd.	--	chenxue_gz@163.com	CHINA	6600	58
Beijing Zhijie Fangyuan Technology Co., Ltd.	--	15810200961@163.com	CHINA	6984	58
Shanghai Jijin Chemical Technology Co., Ltd.	--	jijinhuaxue@sina.com	CHINA	6606	58
Shanghai Hao Zhun Biological Technology Co., Ltd.	--	info@zzsrm.com	CHINA	6650	58
Shanghai Benrui Biotechnology Co., Ltd.	--	john.st@163.com	CHINA	1471	58
Riedel-de Haen AG	--		United States	6773	87

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• 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
• ERK INHIBITOR
• 2,4-Thiazolidinedione, 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-
• 294675-79-9