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TISSUE PLASMINOGEN ACTIVATOR, HUMAN

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Struktur
189263-81-8
CAS-Nr.
189263-81-8
Englisch Name:
TISSUE PLASMINOGEN ACTIVATOR, HUMAN
Synonyma:
TISSUE PLASMINOGEN ACTIVATOR;TPA;TPA, HUMAN;1-CHAIN TPA;2-CHAIN TPA;TISSUE PLASMINOGEN ACTIVATOR, HUMAN;TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN;TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN;9,10-Bis[N-(m-tolyl)anilino]anthracene;9,10-Bis[N-(m-tolyl)anilino]anthracene
CBNumber:
CB3746518
Summenformel:
C40H32N2
Molgewicht:
540.7
MOL-Datei:
189263-81-8.mol

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Eigenschaften

Schmelzpunkt:
262 °C
Siedepunkt:
723.8±53.0 °C(Predicted)
Dichte
1.194±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-0.33±0.50(Predicted)
Aggregatzustand
Lyophilized
Farbe
Light yellow to Yellow to Orange
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36/37/38
S-S?tze: 26-36
WGK Germany  1
HS Code  2921.59.8090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

off-white powder

Verwenden

Tissue plasminogen activator has been used in a study to assess treatment risks of intracranial hemorrhage among patients with acute ischemic stroke. Tissue plasminogen activator has also been used in a study to investigate the successful treatment of early thrombosis of HeartWare left ventricular assist devices with intraventricular thrombolytics. Human tissue plasminogen activator has been used to study the effect of tyrosinase-related protein 2 (TRP-2) expression on melanin production in sheep.

Allgemeine Beschreibung

Recombinant tPA (rtPA), alteplase (Activase), is identicalwith endogenous tPA. rtPA lacks a glycosyl residue atAsn184. At one time, rtPA was produced in two-chain formin CHO cultures. Now, large-scale cultures of recombinanthuman melanoma cells in fermenters are used to produce aproduct that is about 80% single-chain rtPA.
Alteplase is used to improve ventricular function followingan acute myocardial infarction, including reducing the incidenceof congestive heart failure and decreasing mortality.The drug is also used to treat acute ischemic stroke aftercomputed tomography (CT) or other diagnostic imaging hasruled out intracranial hemorrhage. rtPA is also used in casesof acute pulmonary thromboembolism and is being investigatedfor unstable angina pectoris.
Alteplase is supplied as powder for injection, and in reconstitutedform (normal saline or 5% dextrose in water) isintended for IV infusion only. The solution expires in 8 hoursat room temperature and must be prepared just before use.

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


TISSUE PLASMINOGEN ACTIVATOR, HUMAN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 71)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Alfa Chemistry

Info@alfa-chemistry.com United States 24072 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
TCI (Shanghai) Development Co., Ltd. 021-67121386
Sales-CN@TCIchemicals.com China 24529 81
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 031166536426
master@sjzsdyn.com China 2963 65
Adamas Reagent, Ltd. 400-6009262 16621234537
chenyj@titansci.com China 14103 59
Xi’an Caijing Opto-Electrical Science and Technology Co.,Ltd 029-88294447 029-88292246 029-88296135
cjoesale@xacjoe.com China 221 62

189263-81-8()Verwandte Suche:


  • 2-CHAIN TPA
  • 1-CHAIN TPA
  • Tissue Plasminogen Activator from human melanoma cells
  • 9,10-Bis[N-(m-tolyl)anilino]anthracene
  • TISSUE PLASMINOGEN ACTIVATOR, HUMANphenyl)-N,N'-diphenyl-
  • TISSUE PLASMINOGEN ACTIVATOR, HUMAN
  • TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN
  • TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN
  • TPA, HUMAN
  • TPA
  • 9,10-Bis[N-(m-tolyl)anilino]anthracene
  • 9-N,10-N-bis(3-methylphenyl)-9-N,10-N-diphenylanthracene-9,10-diamine
  • 9,10-Anthracenediamine, N9,N10-bis(3-methylphenyl)-N9,N10-diphenyl-
  • N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-9,10-anthracenediamine
  • N,N'-Diphenyl-N,N'-di(m-tolyl)-9,10-anthracenediamine
  • N9,N10-Diphenyl-N9,N10-di-m-tolylanthracene-9,10-diamine
  • TISSUE PLASMINOGEN ACTIVATOR
  • 189263-81-8
  • Serum Related EnzymesEnzymes, Inhibitors, and Substrates
  • Therapeutic EnzymesProteolytic Enzymes and Substrates
  • Tissue Plasminogen Activator
  • Application Index
  • Proteases&Protein Sequencing
  • ProteasesApplication Index
  • Selective Proteolytic Enzymes
  • Serum Proteins and Related Enzymes
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