P1075
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- CAS-Nr.
- 60559-98-0
- Englisch Name:
- P1075
- Synonyma:
- P1075;-3-pyridinyl-guanidine;-(1,1-dimethylpropyl)-N’2-cyano-1-tert-pentyl-3-(3-pyridyl)guanidine;2-cyano-1-tert-pentyl-3-(3-pyridyl)-guanidin;N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE;n-cyano-n’-(1,1-dimethylpropyl)-n’’-3-pyridinyl-guanidin;N-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine;Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-;Inhibitor,Potassium Channel,P1075,KcsA,COS-7,adult rabbit cardiomyocytes,inhibit,P 1075,P-1075
- CBNumber:
- CB3682098
- Summenformel:
- C12H17N5
- Molgewicht:
- 231.3
- MOL-Datei:
- 60559-98-0.mol
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P1075 Eigenschaften
- Schmelzpunkt:
- 186-187 °C
- Siedepunkt:
- 347.6±34.0 °C(Predicted)
- Dichte
- 1.07±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- L?slichkeit
- Soluble to 50 mM in ethanol and to 100 mM in DMSO
- Aggregatzustand
- Powder
- pka
- 4.74±0.11(Predicted)
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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P1075 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
N-Cyano-N''-(1,1-dimethylpropyl)-N''''-3-pyridinyl-guanidine is an ATP-sensitive potassium channels activator or opener (KATPCO) by causing relaxation of various isolated animal and human blood vessels.
Biologische Aktivit?t
Potent K ATP channel opener (EC 50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (K d values are 17 and 3 nM respectively).
Enzyminhibitor
This potent potassium ion channel opener, or KCO (FW = 231.30 g/mol; CAS 60559-98-0; Solubility: 50 mM in Ethanol; 100 mM in DMSO), also known as N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridyl-guanidine, targets Kir6 (or KATP) channels (EC50 = 7.5 nM; for relaxation of rat aorta). In studies on rats, rabbit and dogs, P1075 effects only correlate with the presence of specific receptor binding sites in rat vascular preparations, showing there are significant species-specific and raising questions about the pharmacological significance of this KATP opener binding site. These channels are heteromultimers composed with a 4:4 stoichiometry of an inwardly rectifying K+ channel subunit plus a regulatory subunit comprising the receptor sites for hypoglycemic sulfonylureas and KCOs (a sulfonylurea receptor). P1075-induced channel activation IS mediated by drug interaction with a single binding site per tetradimeric complex. P-1075 also binds to sulfonylurea receptors SUR2A (Kd = 17 nM) and SUR2B (Kd = 3 nM)
P1075 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
P1075 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 45)Lieferanten
60559-98-0()Verwandte Suche:
- P1075
- N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE
- 2-cyano-1-tert-pentyl-3-(3-pyridyl)-guanidin
- 2-cyano-1-tert-pentyl-3-(3-pyridyl)guanidine
- n-cyano-n’-(1,1-dimethylpropyl)-n’’-3-pyridinyl-guanidin
- N-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine
- Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-
- -(1,1-dimethylpropyl)-N&rsquo
- -3-pyridinyl-guanidine
- Inhibitor,Potassium Channel,P1075,KcsA,COS-7,adult rabbit cardiomyocytes,inhibit,P 1075,P-1075
- 60559-98-0
- C12H17N5
- Potassium channel
