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Eplerenone

Eplerenone Struktur
107724-20-9
CAS-Nr.
107724-20-9
Englisch Name:
Eplerenone
Synonyma:
Inspra;EPLERINONE;Eplerenone CRS;Eplerenone [USAN];pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester;PREGNA-4-ENE-7,21-DICARBOXYLIC ACID,11,17-DIHYDROXY-3-OXO,G-LACTONE,METHYLESTER,(7Α,11Α,17Α);(7A,11A,17A)-9,11-EPOXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICARBOXYLIC ACID G-LACTONE METHYL ESTER;SC-66110;Eplenone;HSDB 7522
CBNumber:
CB3489802
Summenformel:
C24H30O6
Molgewicht:
414.49
MOL-Datei:
107724-20-9.mol

Eplerenone Eigenschaften

Schmelzpunkt:
241-243°C
alpha 
D +5° (c = 0.437 in chloroform)
Siedepunkt:
597.9±50.0 °C(Predicted)
Dichte
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
DMSO: soluble2mg/mL, clear (warmed)
Aggregatzustand
powder
Farbe
white to beige
maximale Wellenl?nge (λmax)
240nm(lit.)
Merck 
14,3625
InChIKey
UZZAHAKTLYRDOK-MGIDJNSKSA-N
SMILES
[C@@]123[C@@]4(C)CCC(=O)C=C4C[C@@H](C(OC)=O)[C@@]1([H])[C@]1([H])CC[C@]4(CCC(=O)O4)[C@]1(C[C@@]2([H])O3)C |&1:0,1,10,15,17,21,27,29,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RIDADR  3077
WGK Germany  3
HS Code  29322090
Giftige Stoffe Daten 107724-20-9(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Eplerenone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Eplerenone is a mineralocorticoid receptor antagonist. It is selective for the mineralocorticoid receptor over glucocorticoid, androgen, progesterone, and estrogen receptors in radioligand binding assays (IC50s = 138, 6,920, 523, >10,000, and 5,702 nM, respectively). Eplerenone inhibits aldosterone-induced mineralocorticoid activity in a luciferase assay (IC50 = 122 nM). In vivo, eplerenone (100 mg/kg per day) reduces urinary albumin secretion and glomerulosclerosis in the Dahl salt-sensitive rat model of hypertension and nephropathy. It reduces myocardial IL-1β levels and collagen deposition, as well as improves left ventricular systolic dysfunction in a mouse model of acute myocardial infarction. Formulations containing eplerenone have been used in the treatment of hypertension and heart failure after myocardial infarction.

Chemische Eigenschaften

White Solid

Verwenden

Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.

Allgemeine Beschreibung

Eplerenone, 9,11α-epoxy-17α-hydroxy-3-oxopregn-4-ene-7α,21-dicarboxylic acid, γ-lactone,methyl ester (Inspra), is a newer aldosterone antagonist that isused for the treatment of hypertension.

Biologische Aktivit?t

Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo .

Clinical Use

A newer drug, eplerenone, has a structure similar to that of spironolactone and a similar mechanism of action. It was initially approved for use in the treatment of hypertension but it can now be used in the treatment of patients with left ventricular systolic dysfunction and congestive heart failure after myocardial infarction.

Eplerenone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Eplerenone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 526)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Kangcang new material Technology Co., LTD
+8615713292910
Nancy@kangcang.com.cn China 341 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Hebei Dangtong Import and export Co LTD
+86-13910575315 +86-13910575315
admin@hbdangtong.com China 1000 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+8615350851019
admin@86-ss.com China 1001 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55

107724-20-9()Verwandte Suche:


  • (2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
  • HSDB 7522
  • Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-
  • Eplerenone intermediate Eplerenone
  • (7α,11α,17α)-9,11-epoxy-17-hydroxy-3-oxo-γ-lactone-pregn-4-ene-7,21-dicarboxylic acid-7-methyl ester
  • Eplerenone for system suitability
  • Eplerenone for peak identification
  • EPLERENONE
  • EPLERENONE 98%
  • EPLERENONE USP STANDARD
  • Elperenone
  • EplerenoneC24H3006
  • (7a,11a,17a)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid -Lactone 7-Methyl Ester
  • CGP 30083
  • SC-66110
  • pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo, γ-lactone, methyl ester (7 α, 11 α, 17 α)
  • EPLERENONE AND N-1 INTERMEDIATE
  • epoxymexrenone
  • CGP 30083, Epoxymexrenone, Inspra, Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2(3-furan],pregn-4-ene-7,21-dicarboxylic Acid, Inspra,
  • (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylicacidγ-lactonemethylester
  • Methyl (1'R,2R,2'S,9'R,10'S,11'S,15'S,17'R)-2',15'-diMethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate
  • (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid
  • γ-Lactone 7-Methyl Ester
  • 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic Acid gamma-Lactone Methyl Ester
  • Eplerenone-13C-d3
  • plerenone
  • Eplerenone, 98%, selective mineralocorticoid antagonist
  • INSPRA;EPOXYMEXRENONE
  • Eplerenone for system suitability CRS
  • Eplerenone for peak identification CRS
  • Eplerenone RS
  • Eplerenone>
  • Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
  • Eplerenone USP/EP/BP
  • Eplerenone (Epoxymexrenone
  • Eplerenone D3Q: What is Eplerenone D3 Q: What is the CAS Number of Eplerenone D3 Q: What is the storage condition of Eplerenone D3 Q: What are the applications of Eplerenone D3
  • Eplerenone EPQ: What is Eplerenone EP Q: What is the CAS Number of Eplerenone EP Q: What is the storage condition of Eplerenone EP Q: What are the applications of Eplerenone EP
  • Eplerenone (1237553)
  • Eplerenone [USAN]
  • (7A,11A,17A)-9,11-EPOXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICARBOXYLIC ACID G-LACTONE METHYL ESTER
  • EPLERINONE
  • pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester
  • Inspra
  • Eplerenone CRS
  • PREGNA-4-ENE-7,21-DICARBOXYLIC ACID,11,17-DIHYDROXY-3-OXO,G-LACTONE,METHYLESTER,(7Α,11Α,17Α)
  • Eplerenone Hormone Raw Powder
  • (+)-Eplerenone
  • (2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-methyl 4a,6a-dimethyl-2,5'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
  • Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
  • Eprolidone
  • (2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-dimethyl-2,5'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
  • Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,4'-dioxo-2,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
  • Eplenone
  • 107724-20-9
  • 07724-20-9
  • 107727-20-9
  • C24H30O6
  • Cardiovascular APIs
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