PJ-34
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- CAS-Nr.
- 344458-19-1
- Englisch Name:
- PJ-34
- Synonyma:
- PJ-34;CS-856;PJ34(free base);PJ34;PJ-34;PJ 34;PJ34 PJ-34 A3729 A-3729;2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL;2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;PJ34,Inhibitor,PJ-34,PJ 34,PARP,inhibit,poly ADP ribose polymerase
- CBNumber:
- CB3434387
- Summenformel:
- C17H17N3O2
- Molgewicht:
- 295.34
- MOL-Datei:
- Mol file
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PJ-34 Eigenschaften
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- Solid
- Farbe
- Light yellow to khaki
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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PJ-34 Chemische Eigenschaften,Einsatz,Produktion Methoden
Enzyminhibitor
This PARP inhibitor (FWfree-base = 295.34 g/mol; FWhydrochloride = 331.80 g/mol), systematically named N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)- N,N-dimethylacetamide and known for its activity in neuroprotection under stress conditions, exclusively eradicates multi-centrosomal human mammary, colon, lung, pancreas, ovarian cancer cells, by acting as an extracentrosome extracentrosome( s) de-clustering agent in mitosis. When applied at 20-30 μM, PJ-34 caused G2/M-arrest and a massive cell death Normal human proliferating endothelial, epithelial and mesenchymal cells were unaffected. PJ-34’s cytotoxicity on cancer cells is not attributable to PARP inhibition alone. PJ-34 was originally designed to protect neuronal cells in the central nervous system from cell death evoked by high activity of PARP-1 in response to DNA damage caused by brain injury, stroke or inflammation. Targets: extra-centrosome de-clustering; polyADP-ribose polymerase-1, EC50 = 20 nM
PJ-34 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PJ-34 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 70)Lieferanten
- N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
- N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL
- N-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE
- PJ-34
- PJ34(free base)
- Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-
- N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide
PJ 34
- N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide
- PJ34;PJ-34;PJ 34
- CS-856
- 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
- 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
- PJ34 PJ-34 A3729 A-3729
- PJ34,Inhibitor,PJ-34,PJ 34,PARP,inhibit,poly ADP ribose polymerase
- 344458-19-1
- Inhibitors
