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22(R)-HYDROXYCHOLESTEROL

22(R)-HYDROXYCHOLESTEROL Struktur
17954-98-2
CAS-Nr.
17954-98-2
Englisch Name:
22(R)-HYDROXYCHOLESTEROL
Synonyma:
22R-OHC;22(R)-OH-CH;Narthesterol;22α-hydroxycholesterol;22BF-HYDROXYCHOLESTEROL;Cholesterol 22α-Hydroxy;22α-Hydroxy Cholesterol;22(R)-Hydroxycholestero;Chlorambucil Impurity 8;22(R)-HYDROXYCHOLESTEROL
CBNumber:
CB3350290
Summenformel:
C27H46O2
Molgewicht:
402.65
MOL-Datei:
17954-98-2.mol

22(R)-HYDROXYCHOLESTEROL Eigenschaften

Schmelzpunkt:
171-174°C
Siedepunkt:
513.1±23.0 °C(Predicted)
Dichte
1.03±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
15.01±0.20(Predicted)
Farbe
White to Off-White
InChIKey
RZPAXNJLEKLXNO-QUOSNDFLSA-N

Sicherheit

WGK Germany  3

22(R)-HYDROXYCHOLESTEROL Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. 22(R)-hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRα with an EC50 value of 325 nM. 22(R)-hydroxy Cholesterol, acting through LXR heterodimerized with the retinoid X receptor, induces the expression of the ABCA1 reverse cholesterol transporter. This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22(R)-hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis.

Verwenden

Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.

Definition

ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.

Allgemeine Beschreibung

22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain.

22(R)-HYDROXYCHOLESTEROL Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


22(R)-HYDROXYCHOLESTEROL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 96815 76

17954-98-2()Verwandte Suche:


  • 22α-Hydroxycholesterol, 5-Cholestene-3β,22(R)-diol, 5-Cholestene-3β,22[R]-diol
  • (22R)-Cholest-5-ene-3β,22-diol
  • 22R-OHC
  • (3beta,22R)-Cholest-5-ene-3,22-diol
  • Cholest-5-ene-3,22-diol, (3beta,22R)-
  • (20S,22R)-Cholest-5-ene-3β,22-diol
  • (3β,22R)-Cholest-5-ene-3,22-diol
  • Cholest-5-ene-3β,22(R)-diol
  • Narthesterol
  • 5-Cholestene-3β,22(R)-diol
  • 5-Cholestene-3β,22[R]-diol
  • 22BETA-HYDROXYCHOLESTEROL
  • 22BF-HYDROXYCHOLESTEROL
  • 22-ALPHA-HYDROXYCHOLESTEROL
  • 22(R)-HYDROXYCHOLESTEROL
  • 22(R)-OH-CH
  • 22-HYDROXYCHOLESTEROL (22R)
  • 3BETA,22BETA-DIHYDROXY-5-CHOLESTENE
  • 5-CHOLESTEN-3-BETA, 22(R)-DIOL
  • 5-CHOLESTENE-3BETA,22[R]-DIOL
  • CHOLEST-5-ENE-3BETA,22R-DIOL
  • 22[R]-Hydroxycholesterol (not deuterated)
  • 22α-hydroxycholesterol
  • (22a-Hydroxycholesterol, 5-Cholestene-322(R)-diol)
  • Cholesterol 22α-Hydroxy
  • 22α-Hydroxy Cholesterol
  • 22(R)-Hydroxycholestero
  • Cholest-5-ene-3,22-diol, (3β,22R)-
  • 5-CHOLESTEN-3β, 22(R)-DIOL
  • Chlorambucil Impurity 8
  • 17954-98-2
  • Lipids
  • Sterols
  • Cholesterol and Derivatives
  • BioChemical
  • Biochemicals and Reagents
  • Hydroxycholesterol
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids
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