MG-132
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- CAS-Nr.
- 133407-82-6
- Englisch Name:
- MG-132
- Synonyma:
- CS-216;MG-132;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG-132(SSS);MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H
- CBNumber:
- CB3298042
- Summenformel:
- C26H41N3O5
- Molgewicht:
- 475.62
- MOL-Datei:
- 133407-82-6.mol
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MG-132 Eigenschaften
- Schmelzpunkt:
- 80-84℃ (DEC.)
- alpha
- -61～-67°
- Siedepunkt:
- 682.0±55.0 °C(Predicted)
- Dichte
- 1.073
- Flammpunkt:
- 366℃
- storage temp.
- -20°C
- L?slichkeit
- methanol: 1 mg/mL
- Aggregatzustand
- solid film
- pka
- 11.14±0.46(Predicted)
- Farbe
- White
- Wasserl?slichkeit
- Soluble in ethanol, chloroform, methanol, water.
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
- InChIKey
- TZYWCYJVHRLUCT-VABKMULXSA-N
MG-132 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
A proteasome and NF-κB inhibitor.
Definition
ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is
protected as its benzyloxycarbonyl derivative.
Allgemeine Beschreibung
Potent, reversible, and cell-permeable proteasome inhibitor (K
i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC
50 = 3 μM).
Biologische Aktivit?t
Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .
MG-132 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
MG-132 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 291)Lieferanten
133407-82-6()Verwandte Suche:
- PROTEASOME INHIBITOR MG-132
- N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N-[(1S)-1-FORMYL-3-METHYLBUTYL]-L-LEUCINAMIDE
- N-CBZ-LEU-LEU-LEUCINAL
- Z-LLL-CHO
- Z-LL-CHO
- Z-LEU-LEU-LEU-CHO
- Z-LEU-LEU-LEU-H
- Z-LEU-LEU-LEU-H (ALDEHYDE)
- Z-LEU-LEU-LEU-ALDEHYDE
- Z-LEU-LEU-ALDEHYDE
- N-cbz-leu-leu-leu-al
- z-leu-leu-leu-al
- CALPAIN INHIBITOR IV
- CARBOBENZOXY-L-LEUCYL-L-LEUCYL-LEUCINAL
- CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL
- BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-LEUCINAL
- benzyloxycarbonylleucyl-leucyl-leucinealdehyde
- (S)-MG132
- N-carbobenzyloxy-Leu-Leu-Leu-al
- MG-132;Z-LEU-LEU-LEU-AL
- Z-Leu-Leu-Leu-al,MG132
- Calpain inhibitor IV-2
- L-LeucinaMide, N-[(phenylMethoxy)carbonyl]-L-leucyl-N-[(1S)-1-forMyl-3-Methylbutyl]-
- MG132/MG-132
- MG-132 [Z-Leu-Leu-Leu-CHO]
- Z-LEU-LEU-LEU-AL, >=90% (HPLC)
- Benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylami
- InSolution? MG-132
- MG-132, ≥95% by HPLC
- N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
- benzyl ((S)-4-Methyl-1-(((S)-4-Methyl-1-(((S)-4-Methyl-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)aMino)-1-oxopentan-2-yl)carbaMate
- MG 132
Calpain inhibitor IV-2
- N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide Calpain inhibitor IV-2 MG 132
- MG-132, >=98%
- MG 132;MG132;Z-LEU-LEU-LEU-CHO;CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL
- MG132, 98%, proteasome inhibitor
- CS-216
- MG-132 - CAS 133407-82-6 - Calbiochem
- MG-132, ≥95% by HPLC - CAS 133407-82-6 - Calbiochem
- InSolution MG-132 - CAS 133407-82-6 - Calbiochem
- benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
- Z-LLL-al
- 133407-82-6 MG-132 C26H41N3O5
- MG-132
- MG-132,Inhibitor,MG132,MG 132,complex,peptide,calpain,Autophagy,proteolytic,Proteasome,aldehyde,inhibit,Apoptosis,26S
- MG-132 solution (10mM/L)
- MG-132(SSS)
- MG-132 (Ethanol Solution)
- (S)-2-(Cbz-amino)-4-methyl-N-[(S)-4-methyl-1-[[(S)-4-methyl-1-oxo-2-pentyl]amino]-1-oxo-2-pentyl]pentanamide
- 133407-82-6
- C26H41N3O5
- Cell Signaling Enzymes
- BioChemical
- Biochemicals and Reagents
- Application Index
- Enzymes, Inhibitors, and Substrates
- Proteasome, Calpain and Lysosomal Proteases
- Proteasomes
