Anti-Ran-binding protein 21 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
XPO5 (exportin 5) is a Ran-GTP-dependent nuclear transport protein for double-stranded RNA binding proteins. It belongs to the karyopherin protein family which is involved in nucleus to cytoplasm transport of specific classes of small RNAs.
Biochem/physiol Actions
XPO5 (exportin 5) is responsible for the translocation of miRNA (micro-RNA) precursor from nucleus to cytoplasm. Studies in HeLa cells show that miR-138 lowers the stability of XPO5 protein, thus, decreasing miRNA processing. This protein is also involved in the transport of short hairpin (shRNA). It docks on the nuclear pore complex and transports three classes of RNAs, tRNA, Y-RNA and miRNA precursors, across the nuclear membrane, in a RanGTP-RanGDP gradient-dependent manner.
Anti-Ran-binding protein 21 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
