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ANTI-C-FMS

ANTI-C-FMS Struktur
CAS-Nr.
Englisch Name:
ANTI-C-FMS
Synonyma:
ANTI-C-FMS;Anti-CD115 antigen;Anti-Fms proto-oncogene;Colony stimulating factor 1 receptor;Anti-CSF1R antibody produced in goat;Anti-CSF1R antibody produced in rabbit;Anti-Macrophage colony-stimulating factor 1 receptor precursor
CBNumber:
CB3282047
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-C-FMS Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous glycerol solution

Sicherheit

Kennzeichnung gef?hrlicher Xn
R-S?tze: 22

ANTI-C-FMS Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-CSF1R antibody has been used:
  • in cell lysis
  • in immunoprecipitation
  • in western blotting
  • in immunohistochemical analysis

Allgemeine Beschreibung

CSF1R (Colony stimulating factor 1 receptor), a type III receptor tyrosine kinase, is a member of the platelet-derived growth factor (PDGF) receptor family. Structurally, it is composed of five immunoglobulin-like domains, a transmembrane domain, a juxtamembrane domain (JM) and a protein kinase domain separated into two parts by an insert domain (KID).

Biochem/physiol Actions

CSF1R (Colony stimulating factor 1 receptor) is a major molecule in the innate immunity, cancer, and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. It regulates developmental activities including cell survival, proliferation, differentiation, and function of mononuclear phagocytes. It has been reported that CSF-1 autocrine loop helps to activate macrophages. In actual state, it exists as an autoinhibited form, and upon activation, it dimerizes. Later, it autophosphorylates tyrosine residues in the intracellular domain, followed by the recruitment of signaling molecules as well as internalization of the receptor. Mutation in the CSF1R causes several diseases including myeloid malignancies.

ANTI-C-FMS Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-C-FMS Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Riedel-de Haen AG --
United States 6773 87
Chemicon Internatinal, Inc. --
custserv@chemicon.com United States 4175 65

  • ANTI-C-FMS
  • Anti-CD115 antigen
  • Anti-CSF1R antibody produced in rabbit
  • Anti-Fms proto-oncogene
  • Anti-Macrophage colony-stimulating factor 1 receptor precursor
  • Anti-CSF1R antibody produced in goat
  • Colony stimulating factor 1 receptor
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