API-2
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- CAS-Nr.
- 35943-35-2
- Englisch Name:
- API-2
- Synonyma:
- TCN;IAP1;MIHC;MYHL;BBMI;API-2;BIRC3;RNF49;MYO1A;DFNA48
- CBNumber:
- CB3270000
- Summenformel:
- C13H16N6O4
- Molgewicht:
- 320.3
- MOL-Datei:
- 35943-35-2.mol
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API-2 Eigenschaften
- Schmelzpunkt:
- 207 °C (decomp)
- Siedepunkt:
- 459.21°C (rough estimate)
- Dichte
- 1.2633 (rough estimate)
- Brechungsindex
- 1.7000 (estimate)
- storage temp.
- Store at RT
- L?slichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- powder
- pka
- 12.35±0.70(Predicted)
- Farbe
- tan
- InChIKey
- HOGVTUZUJGHKPL-HTVVRFAVSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| RTECS-Nr. |
RY8455000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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API-2 Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-White Solid
Biologische Aktivit?t
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
API-2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
API-2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 154)Lieferanten
35943-35-2()Verwandte Suche:
- API-2
- 6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE
- AKT/PKB SIGNALING INHIBITOR-2
- AKT INHIBITOR V
- 1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE
- 1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura
- API-2 (Tricirbine)
- TRICIRIBINE
- NSC 154020
- TCN
- 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
- (1,4,5,6,8-Pentaazaacenaphthylen-3-aMine,1,5-dihydro-5-Methyl-1-b-D-ribofuranosyl-)
- 6-AMino-4-Methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyriMido[4,5-c]pyridazine
- (2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
- VD-0002
- 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine
- Triciribine
1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
- Inhibitor V
- (1R,2S,3R,5R)-3-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)c
- InSolution? Akt Inhibitor V, Triciribine
- Triciribine hydrate
- ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit
- BIRC3
- IAP1
- MIHC
- RNF49
- ANTI-MYO1A (CENTER S291) antibody produced in rabbit
- Brush border myosin I
- MYHL
- Myosin-Ia
- Anti-MYO1A antibody produced in rabbit
- BBMI
- DFNA48
- MYO1A
- Anti-Dfna48
- Anti-Myhl
- Anti-Myosin ia
- Triciribine, >=98%
- 1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof
- 3-amine
- 3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap
- 4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1
- hthylene
- nosyl-
- pentaazacentopthylene
- uranosyl-
- TRICYCLIC NUCLEOSIDE
- CS-542
- API-2; NSC 154020; TCN
- CS-690
- Triciribine, NSC 154020, TCN
- InSolution Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
- Triciribine (NSC-154020)
- Triciribine, 98%, a DNA synthesis inhibitor
- Tricirbine
- 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-D-ribofuranosyl-
- API-2 USP/EP/BP
- Triciribine 13CD3
