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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Struktur
950912-80-8
CAS-Nr.
950912-80-8
Englisch Name:
4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
Synonyma:
CS-318;PF 67046;PF 670462;PF-670462 HCL;PF-670462 2HCl;PF 670462, >=98%;PF670462/ PF-670462;PF670462 dihydrochloride;PF-670462, 10 mM in DMSO;PF-670462 (hydrochloride)
CBNumber:
CB32518984
Summenformel:
C19H20FN5.2HCl
Molgewicht:
410
MOL-Datei:
950912-80-8.mol

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Eigenschaften

Schmelzpunkt:
>178°C (dec.)
storage temp. 
2-8°C
L?slichkeit
H2O: soluble2mg/mL, clear (warmed)
Aggregatzustand
powder
Farbe
white to beige
Wasserl?slichkeit
H2O: 2mg/mL, clear (warmed)
InChIKey
PSNKGVAXBSAHCH-UHFFFAOYSA-N
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related or common kinases. Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals. It also blocks the locomotor response to amphetamines in mice.

Verwenden

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.

Definition

ChEBI: A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selectiv inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • PF670462/ PF-670462
  • 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride
  • 2-PyriMidinaMine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-iMidazol-5-yl]-, hydrochloride (1:2)
  • PF 67046
  • 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride PF670462
  • 4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride
  • PF 670462, >=98%
  • PF 670462
  • PF-670462 2HCl
  • PF-670462 (hydrochloride)
  • Casein Kinase I Inhibitor II, PF-670462
  • 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
  • 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine:dihydrochloride
  • Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem
  • 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
  • CS-318
  • PF670462 dihydrochloride
  • PF-670462 HCL
  • PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor
  • PF-670462, 10 mM in DMSO
  • 950912-80-8
  • C19H20FN52HCl
  • C19H22Cl2FN5
  • C19H20FN52ClH
  • Inhibitors
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators
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