TRIMIDOX Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ribonucleotide reductase, the rate-
limiting enzyme for
de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-
60 cells, inducing apoptosis
via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-
60 cells with an IC
50 value of 35 μM.
Verwenden
Trimidox is a specific ribonucleotide reductase inhibitor.
TRIMIDOX Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte