Anti-G3BP1, Anti-GAP SH3 domain-binding protein, Anti-HDH-VIII, Anti-human DNA helicase VIII, Anti-Ras-GTPase-activating protein SH3-domain binding protein 1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-G3BP antibody produced in rabbit has been used in co-immunoprecipitation assay.

Allgemeine Beschreibung

G3BP is a RNA-binding protein that contains a RNA binding domain, the RRM-type domain, at the carboxyl-terminal. The N-terminal domain is homologous to nuclear transporter factor 2 (NTF2) and the central domain is rich in acidic residues. The RRM domain is involved in the binding of G3BP to specific RNA sequences. This helps G3BP to function as a CA dinucleotide-specific endoribonuclease. G3BP′s subcellular localization and protein-protein interactions are mediated by the phosphorylation of G3BP at Ser¹⁴⁹, near NTF2-like domain. G3BP is found in abundance in many kinds of malignant tumors such as lung, colon, gastric, and breast cancer.

Biochem/physiol Actions

G3BP (Ras-GTPase-activating protein SH3 domain binding protein 1) is a endoribonuclease that is phosphorylation-dependent and specific to single strand. It cleaves between cytosine and adenine (CA). It binds to the SH3 domain of RasGAP. It forms a link between RasGAP-mediated signaling pathway and RNA turnover. G3BP is required for the assembly of stress granules (SGs), which are involved in the regulation of mRNA metabolism during stress. It may be used as a cytoplasmic SG marker.

Anti-G3BP1, Anti-GAP SH3 domain-binding protein, Anti-HDH-VIII, Anti-human DNA helicase VIII, Anti-Ras-GTPase-activating protein SH3-domain binding protein 1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Anti-G3BP1, Anti-GAP SH3 domain-binding protein, Anti-HDH-VIII, Anti-human DNA helicase VIII, Anti-Ras-GTPase-activating protein SH3-domain binding protein 1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Shanghai guandao biology engineering co., ltd	18818239863	3171921642@qq.com	China	9044	58

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• Anti-G3BP antibody produced in rabbit
• Anti-G3BP1, Anti-GAP SH3 domain-binding protein, Anti-HDH-VIII, Anti-human DNA helicase VIII, Anti-Ras-GTPase-activating protein SH3-domain binding protein 1
• Anti-phospho-G3BP (pSer149) antibody produced in rabbit
• Anti-ATP-dependent DNA helicase VIII
• Anti-G3BP1 antibody produced in rabbit
• Anti-GAP SH3 domain-binding protein 1
• Anti-Ras GTPase-activating protein-binding protein 1
• Anti-Ras-GTPase-activating protein SH3-domain-binding protein
• Monoclonal Anti-G3BP antibody produced in mouse
• Anti-G3BP1
• Anti-GAP SH3 domain-binding protein
• Anti-HDH-VIII
• Anti-human DNA helicase VIII
• Anti-Ras-GTPase-activating protein SH3-domain binding protein 1