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MONOCLONALANTIBODIES

MONOCLONALANTIBODIES Struktur
CAS-Nr.
Englisch Name:
MONOCLONALANTIBODIES
Synonyma:
MONOCLONALANTIBODIES
CBNumber:
CB31434913
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

MONOCLONALANTIBODIES Eigenschaften

storage temp. 
-20°C

Sicherheit

MONOCLONALANTIBODIES Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Monoclonal antibodies (mAbs) are powerful tools for tracking microorganisms because they can recognize epitopes on the surface of bacteria and thus serve as in situ identifiers. A series ofmAbs were produced against whole cells of Pseudomonas putida KT2440 (84). One was shown to recognize the O-antigen of P. putida LPS. In the laboratory, this mAb specifically recognized the strain when grown in different culture media and at different growth stages.

Verwenden

The mAb was used to track the strain after its release in a mesocosm established in Plussee Lake in northern Germany (85).

Allgemeine Beschreibung

A monoclonal antibody target for the treatment of osteoporosisis the RANKL, which is the essential mediator of osteoclasts.As pointed out in the osteoporosis discussion, theloss of calcium by increased osteoclastic activity and decreasedosteoclast apoptosis is opposed by a RANKLinhibitor, osteoprotegerin a 401-amino acid glycoprotein,and a member of the TNF superfamily. Rather than developa pharmaceutically acceptable osteoprotegerin, a fullyhuman monoclonal antibody, denosumab, that binds to theRANKL preventing its binding to RANK is being evaluatedfor the treatment of osteoporosis. The reported result is inhibitionof all stages of osteoclast activity. It is important tokeep a perspective when administering drugs that interferewith the immune system over long periods of time. RANKLis part of the normal bone remodeling process as well aswith pathological bone loss. The key is balance, and thiswill require long-term studies in patients with postmenopausalosteoporosis.

MONOCLONALANTIBODIES Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


MONOCLONALANTIBODIES Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Maxcell Systems Pvt. Ltd. --
India 8 58
Riedel-de Haen AG --
United States 6773 87

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