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FASUDIL

FASUDIL Struktur
103745-39-7
CAS-Nr.
103745-39-7
Englisch Name:
FASUDIL
Synonyma:
at877;FASUDIL;Fasudilum;Fasudil HCI;HA-1077：Eril;FASUDIL USP/EP/BP;Fasudil Hydrchloride;Fasudil hydrochlorid;Fasudilum [inn-latin];H-1077 dihydrochloride
CBNumber:
CB3101698
Summenformel:
C14H17N3O2S
Molgewicht:
291.37
MOL-Datei:
103745-39-7.mol

FASUDIL Eigenschaften

Siedepunkt:
506.2±60.0 °C(Predicted)
Dichte
1.289±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
H2O: >200 mg/mL
Aggregatzustand
solid
pka
9.73±0.20(Predicted)
Farbe
white
Wasserl?slichkeit
Soluble in water or DMSO
CAS Datenbank
103745-39-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. HM4031166
HS Code  29334900
Toxizit?t mouse,LD50,unreported,73500ug/kg (73.5mg/kg),United States Patent Document. Vol. #4678783,
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

FASUDIL Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White Crystalline Solid

Verwenden

Fasudil is a protein kinase A inhibitor and may be used in medicinal combinations for hepatitis treatment.

Allgemeine Beschreibung

A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 μM), protein kinase G (Ki = 1.6 μM), and myosin light chain kinase (Ki = 3.6 μM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 μM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.

Biologische Aktivit?t

Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM). Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells.

FASUDIL Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Isochinolin

Downstream Produkte

Fasudil hydrochloride

FASUDIL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 189)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325
 sales1@chuanghaibio.com China 5889 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12835 58
SIMAGCHEM CORP 		+86-13806087780
 sale@simagchem.com China 17365 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58

103745-39-7()Verwandte Suche:

  • Fasudil Hydrochloride Injection
  • 1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE
  • at877
  • hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine
  • HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE
  • HA 1077, DIHYDROCHLORIDE, 99+%
  • FASUDIL
  • Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
  • 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-
  • Fasudilum
  • Fasudilum [inn-latin]
  • HA-1077：Eril
  • 2,3,4,5,6,7-Hexahydro-1-(isoquinolin-5-ylsulfonyl)-1H-1,4-diazepine
  • 5-(Hexahydro-1H-1,4-diazepine-1-ylsulfonyl)isoquinoline
  • H-1077 dihydrochloride
  • HA-1077 Dihydrochloride Salt >99%
  • 1-(5-Isoquinolinesulfonyl)homopiperazine, Dihydrochloride Salt
  • 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline dihydrochloride
  • 5-(AZEPAN-4-YLSULFONYL)ISOQUINOLINE DIHYDROCHLORIDE
  • Fasudil HCI
  • 5-(1,4-diazepan-4-ium-1-ylsulfonyl)isoquinoline
  • Fasudil Hydrchloride
  • Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-
  • FASUDIL USP/EP/BP
  • Fasudil hydrochlorid
  • High Quality API Intermediate Fasudil
  • (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE
  • 103745-39-7
  • C14H17N3O2S2HCl
  • C14H17N3O2S2ClH
  • Signalling
  • Protein Kinase Inhibitors and Activators
  • Protein Kinase
  • Angiogenesis and Metastasis
  • Intracellular signaling
  • ERIL
  • APIs
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