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Muzolimine

Muzolimine Struktur
55294-15-0
CAS-Nr.
55294-15-0
Englisch Name:
Muzolimine
Synonyma:
Edrul;Muzolimine;BAY-g-2821;Muzolimina;Muzoliminum;5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one;3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one;3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one;3H-Pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-
CBNumber:
CB2875411
Summenformel:
C11H11Cl2N3O
Molgewicht:
272.13
MOL-Datei:
55294-15-0.mol

Muzolimine Eigenschaften

Schmelzpunkt:
127-129°
Siedepunkt:
401.4±55.0 °C(Predicted)
Dichte
1.5374 (rough estimate)
Brechungsindex
1.5500 (estimate)
pka
3.30±0.50(Predicted)
Aggregatzustand
Solid
Farbe
Light yellow to yellow

Sicherheit

Toxizit?t LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann)

Muzolimine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Muzolimine is a structurally novel, pyrazolone diuretic with a high-ceiling profile. It is somewhat slower in onset than furosemide, but has a more prolonged effect, similar to the thiazides. Muzolimine has been shown to be effective in edema of cardiac, hepatic and renal origin. It also appears to be effective as an antihypertensive agent.

Verwenden

Diuretic; antihypertensive.

Weltgesundheitsorganisation (WHO)

Reports of neurological adverse effects, including paraesthesiae and paralyses, associated with prolonged use of high dosages of muzolimine, were received shortly after its introduction in 1984.

Muzolimine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Muzolimine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one
  • BAY-g-2821
  • Edrul
  • 3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one
  • Muzolimine
  • 3H-Pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-
  • Muzolimina
  • Muzoliminum
  • 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one
  • 55294-15-0
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