FFAR4 (GPR120) (N-Term) Polyclonal Antibody Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
GPR120 is a G protein-
coupled receptor (GPCR) expressed in adipocytes and pro-
inflammatory macrophages that is activated by long chain free fatty acids. The activation of GPR120 results in elevated calcium ion and activation of the ERK cascade. ω-
3 Fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid initiate GPR120 signaling resulting in inhibition of toll-
like receptor and TNF-
α inflammatory signaling pathways in a β-
arrestin2/TAB1 dependent manner. The anti-
inflammatory effects of GPR120 are indirectly involved with promoting insulin secretion. GPR120 also mediates free fatty acid induced apoptosis inhibition in the enteroendocrin cell line STC-
1. Cayman’s N-
terminal polyclonal antibody detects GPR120 in LoVo and PC3 cell lysates. The predicted size for GPR120 is 42.2 kDa and the observed size is approximately 45 kDa by western blot.
FFAR4 (GPR120) (N-Term) Polyclonal Antibody Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
