PKI-179 (hydrochloride) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PKI-179 is an orally bioavailable dual inhibitor of PI3K and mammalian target of rapamycin (mTOR). In an in vitro enzymatic assay, it potently inhibits PI3K (IC₅₀s = 8, 24, 17, and 74 nM for isoforms α, β, δ, and γ, respectively), two common PI3Kα mutants, E545K and H1047R (IC₅₀s = 14 and 11 nM, respectively), and mTOR (IC₅₀ = 0.42 nM). PKI-179 is selective for PI3K and mTOR over a panel of 361 other kinases at IC₅₀ values up to 50 μM, hERG (IC₅₀ > 30 μM), and cytochrome P450 (CYP) isoforms (IC₅₀s > 30 μM), but does have activity for CYP2C8 (IC₅₀ = 3 μM). It inhibits proliferation through the Akt/mTOR signaling pathway in MDA-361 breast and PC3MM2 prostate cancer cell lines in vitro (IC₅₀s = 22 and 29 nM, respectively) and inhibits tumor growth in an MDA-361 mouse xenograft model when used at a dose of 50 mg/kg.

PKI-179 (hydrochloride) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PKI-179 (hydrochloride) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19885	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19704	58
	4008-099-669	23419001name@qq.com	CHINA	73043	58

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• PKI-179 (hydrochloride)
• N-[4-[4-(4-morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N'-4-pyridinyl-urea,monohydrochloride
• PKI179 hydrochloride,PKI 179 hydrochloride
• 1463510-35-1
• C25H28N8O3ClH