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DENDROTOXIN-K

DENDROTOXIN-K Struktur
CAS-Nr.
Englisch Name:
DENDROTOXIN-K
Synonyma:
DENDROTOXIN-K
CBNumber:
CB2411934
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

DENDROTOXIN-K Eigenschaften

storage temp. 
−20°C
Aggregatzustand
lyophilized powder

Sicherheit

RIDADR  UN 3462 6.1/PG 3
WGK Germany  3

DENDROTOXIN-K Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells. It has also been used as a selective blocker of Kv channels in mice.

Biochem/physiol Actions

Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors.

DENDROTOXIN-K Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DENDROTOXIN-K Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 10)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80

  • DENDROTOXIN-K
  • Voltage-gated Ion Channels
  • Ion Channels
  • Potassium Channel Modulators
  • Monovalent Ion Channels
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Monovalent Ion Channels
  • Potassium Channel Modulators
  • Voltage-gated Ion Channels
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