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Clindamycinhydrochlorid

Clindamycin hydrochloride Struktur
21462-39-5
CAS-Nr.
21462-39-5
Bezeichnung:
Clindamycinhydrochlorid
Englisch Name:
Clindamycin hydrochloride
Synonyma:
CLINDAMYCIN HCL;ClindaMycin-d3;CLEOCIN;Dalacin;7(S)-CHLORO-7-DEOXYLINCOMYCIN;Clindamycin hydrochloride, nonsterile;U-21251F;dalacina;Dalacin S;Clidamacin
CBNumber:
CB2398837
Summenformel:
C18H34Cl2N2O5S
Molgewicht:
461.44
MOL-Datei:
21462-39-5.mol

Clindamycinhydrochlorid Eigenschaften

Schmelzpunkt:
141°C
storage temp. 
2-8°C
L?slichkeit
H2O: 50 mg/mL, clear, colorless
Aggregatzustand
Solid
Farbe
White to Off-White
BRN 
4070786
Stabilit?t:
Hygroscopic
InChIKey
AUODDLQVRAJAJM-XJQDNNTCSA-N
SMILES
[C@@H]1([C@@H]([C@H](C)Cl)NC(=O)[C@@H]2C[C@@H](CCC)CN2C)[C@H](O)[C@H](O)[C@H]([C@@H](SC)O1)O.Cl |&1:0,1,2,8,10,17,19,21,22,r|
CAS Datenbank
21462-39-5(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36-37/39
WGK Germany  2
RTECS-Nr. GF2275000
10
HS Code  29419000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H362 Kann S?uglinge über die Muttermilch sch?digen. Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P263 Kontakt w?hrend der Schwangerschaft /und der Stillzeit vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Clindamycinhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

White Solid

Verwenden

Clindamycin hydrochloride is a salt of clindamycin, a semi-synthetic lincosamide. The hydrochloride salt forms at the basic N-ethylproline moiety and is the preferred pharmaceutical formulation. Like other members of the lincosamide family, clindamycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin hydrochloride acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Clindamycin hydrochloride has been extensively studied with over 8,000 literature citations.

Allgemeine Beschreibung

Chemical structure: macrolide

Kontakt-Allergie

This lincosanide antibiotic is used in topical form for acne, or systemically has been responsible for exanthematous rashes and acute generalized exanthematous pustulosis.

Clinical Use

Clindamycin is recommended for the treatment of a widevariety of upper respiratory, skin, and tissue infections causedby susceptible bacteria. Its activity against streptococci,staphylococci, and pneumococci is indisputably high, and it isone of the most potent agents available against somenon–spore-forming anaerobic bacteria, the Bacteroides spp.in particular. An increasing number of reports of clindamycin-associated GI toxicity, which range in severity fromdiarrhea to an occasionally serious pseudomembranous colitis,have, however, caused some clinical experts to call for areappraisal of the role of this antibiotic in therapy.Clindamycin- (or lincomycin)-associated colitis may be particularlydangerous in elderly or debilitated patients and hascaused deaths in such individuals. The colitis, which is usuallyreversible when the drug is discontinued, is now believedto result from an overgrowth of a clindamycin-resistant strainof the anaerobic intestinal bacterium Clostridium difficile.229The intestinal lining is damaged by a glycoprotein endotoxinreleased by lysis of this organism.
The glycopeptide antibiotic vancomycin has been effectivein the treatment of clindamycin-induced pseudomembranouscolitis and in the control of the experimentally induced bacterial condition in animals. Clindamycin shouldbe reserved for staphylococcal tissue infections, such as cellulitisand osteomyelitis, in penicillin-allergic patients andfor severe anaerobic infections outside the central nervoussystem. Ordinarily, it should not be used to treat upper respiratorytract infections caused by bacteria sensitive to othersafer antibiotics or in prophylaxis.

Clindamycinhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Clindamycinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 677)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Zibo Wei Bin Import & Export Trade Co. Ltd.
+86-0533-2091136 +8613864437655
ziboweibinmaoyi@163.com China 100 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Wuhan Han Sheng New Material Technology Co.,Ltd
+8617798174412
admin01@hsnm.com.cn China 2097 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838
evan@tyvovo.com China 148 58
Wuhan Marco Pharmaceutical Technology Co., Ltd.
+86-18572802410 +86-18572802410
sales@marcopht.com China 30 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58

21462-39-5(Clindamycinhydrochlorid)Verwandte Suche:


  • Clindamycin IMP
  • CLINDAMYCIN HYDROCHLORIDE, LINCOSAMI
  • Clindamycin hydrochloride, nonsterileUSP, ≥ 860 μg/mg
  • (2S-TRANS)-METHYL 7-CHLORO-6,7,8-TRIDEOXY-6[[(1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL]AMINO]-1-THIO-L-THREO-ALPHA-D-GALACTO-OCTOPYRANOSIDE
  • (7S)-7-CHLORO-7-DEOXYLINCOMYCIN HYDROCHLORIDE
  • 7(S)-CHLORO-7-DEOXYLINCOMYCIN HCL
  • 7[S]-CHLORO-7-DEOXYLINCOMYCIN HYDROCHLORIDE
  • CLEOCIN HYDROCHLORIDE
  • CLINDAMYCIN HYDROCHLORIDE
  • U-21251F
  • (2S-trans)-Methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octothiopyranoside monohydrochloride
  • (7S)-7-Chloro-7-deoxylincomycin hydrochloride, Cleocin
  • 7-chloro-7-deoxylincomycinhydrochloride
  • clindimycinhydrochloride
  • clindomycinhydrochloride
  • dalacina
  • Clidamacin
  • Dalacin S
  • Panancocin
  • (2S-trans)-Methyl 7-Chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-Methyl-4-propyl-2- pyrrolidinyl]carbonyl]aMino]-1-thio-
  • ClindaMycin hydrochloride Antipyrotic
  • ClindaMycin HCL USP30 EP5 BP2007
  • Clindamycin Base & Phosphate
  • Clindamycin hydrochloride,(7S)-7-Chloro-7-deoxylincomycin hydrochloride, Cleocin
  • 7-Chloro-7-deoxylincoMycin hydrochloride, 7-ChlorolincoMycin hydrochloride
  • (L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1))
  • Clindaymcin Hydrochloride BP98,USP25,EP97
  • L-threo-.alpha.-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, monohydrochloride
  • CLINDAMYCINHYDROCHLORIDE,CRYSTAL
  • CLINDAMYCINHYDROCHLORIDE,USP
  • Clindamycin hydrochloride, Antibiotic for Culture Media Use Only
  • CLINDAMYCIN HC
  • Lujiemycin
  • monohydrochloride,(2s-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio
  • CLINDAMYCIN HCI
  • (7S)-7CHLORO-7-DEOXYLINCOMYCIN HCL
  • (2S-trans)-Methyl 7-Chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2- pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galactooctopyranoside Hydrochloride
  • Clindamycin hydrochloride Solution, 1000ppm
  • Clindamycin Impurity 14(Clindamycin Phosphate EP Impurity E)
  • (4R)-N-[(1S,2S)-2-chloro-1-[(3R,4R,6R)-3,4,5-trihydroxy-6-(methylthio)-2-oxanyl]propyl]-1-methyl-4-propyl-2-pyrrolidinecarboxamide hydrochloride
  • Methyl-7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside hydrochloride
  • Clindamycin hydrochloride CRS
  • Clinimycin HCl
  • Sobelin HCl
  • indamycin HydrochL
  • Clindamycin hydrochloride solution in Methanol, 1000ug/ml
  • Clindamycin hydrochloride (USP, EP, oral grade)
  • (2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride
  • Clindamycin hydrochloride salt
  • lindamycin hydrochloride
  • Clindamycin HydrochlorideQ: What is Clindamycin Hydrochloride Q: What is the CAS Number of Clindamycin Hydrochloride Q: What is the storage condition of Clindamycin Hydrochloride Q: What are the applications of Clindamycin Hydrochloride
  • Clindamycin 13C D3 HydrochlorideQ: What is Clindamycin 13C D3 Hydrochloride Q: What is the CAS Number of Clindamycin 13C D3 Hydrochloride Q: What is the storage condition of Clindamycin 13C D3 Hydrochloride Q: What are the applications of Clindamycin 13C D3 Hydrochloride
  • Clindamycin Hydrochloride (Cleocin)
  • Clindamycin hydrochloride API
  • CLEOCIN
  • CLINDAMYCIN HCL
  • Clindamycin hydrochloride, nonsterile
  • Dalacin
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