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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Struktur
40254-90-8
CAS-Nr.
40254-90-8
Englisch Name:
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
Synonyma:
NSC 693868;Brimonidine Impurity 8;Cdk1/5 Inhibitor inhibitor;3-Aminopyrazolo[3,4-b]quinoxaline;1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
CBNumber:
CB2381002
Summenformel:
C9H7N5
Molgewicht:
185.19
MOL-Datei:
40254-90-8.mol

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Eigenschaften

Schmelzpunkt:
292-293℃ (ethanol )
Siedepunkt:
522.8±45.0 °C(Predicted)
Dichte
1.570±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
L?slichkeit
Soluble to 100 mM in DMSO
Aggregatzustand
Red solid
pka
7.40±0.50(Predicted)
Farbe
Orange to red

Sicherheit

Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45
RIDADR  UN 2811 6.1 / PGIII

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC50 = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.

Verwenden

Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.

Biologische Aktivit?t

Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

3-Chloroquinoxaline-2-carbonitrile

Downstream Produkte

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 51)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+8613564774135
 zijue.cai@tsbiochem.com United States 19885 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136
 Sales@ATKchemical.com China 7295 58
BOC Sciences --
 info@bocsci.com USA 0 65
Jinan blalong chemical co. LTD 2710913286@.com
 1513643261@qq.com China 14246 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
  • 1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE
  • 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
  • NSC 693868
  • 1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI)
  • 3-Aminopyrazolo[3,4-b]quinoxaline
  • 1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine
  • Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
  • Brimonidine Impurity 8
  • Cdk1/5 Inhibitor inhibitor
  • 40254-90-8
  • C9H7N5
  • Protein Kinase
  • PIPERIDINE
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