Mirogabalin
|
|
- CAS-Nr.
- 1138245-13-2
- Englisch Name:
- Mirogabalin
- Synonyma:
- Asapiprant;2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid;DS5565;A200-0700;Milobarin;mirobalin;Miluobalin;Mirogabalin;Mirogabalin HCl;DS5565;A200-0700
- CBNumber:
- CB23051612
- Summenformel:
- C12H19NO2
- Molgewicht:
- 209.28
- MOL-Datei:
- 1138245-13-2.mol
|
Mirogabalin Eigenschaften
- Siedepunkt:
- 357.5±15.0 °C(Predicted)
- Dichte
- 1.104±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- DMF:0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Ethanol:1.25(Max Conc. mg/mL);5.97(Max Conc. mM)
PBS (pH 7.2):0.5(Max Conc. mg/mL);2.39(Max Conc. mM)
Water:5.36(Max Conc. mg/mL);25.61(Max Conc. mM)
- Aggregatzustand
- A crystalline solid
- pka
- 4.65±0.10(Predicted)
- Farbe
- Light yellow to light brown
- InChI
- InChI=1S/C12H19NO2/c1-2-8-3-9-5-12(7-13,6-11(14)15)10(9)4-8/h4,9-10H,2-3,5-7,13H2,1H3,(H,14,15)/t9-,10-,12-/m1/s1
- InChIKey
- FTBQORVNHOIASH-CKYFFXLPSA-N
- SMILES
- [C@]12([H])[C@]([H])([C@@](CN)(CC(O)=O)C1)C=C(CC)C2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
|
Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
|
|
Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
Mirogabalin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Mirogabalin is a calcium channel blocker with analgesic effects. It binds to the α
2δ-1 and α
2δ-2 subunits of voltage-dependent Ca
2+ channels. Mirogabalin has potent and sustained analgesic effects (ED
50 = 2.5 mg/kg) in rats with diabetes induced by streptozotocin (STZ; ). Mirogabalin does not inhibit activities associated with CNS adverse effects of analgesics, such as rotarod performance (ID
50 = 9.4 mg/kg) or locomotor activity (ID
50 = 43.9 mg/kg), at its effective dose. Formulations containing mirogabalin are in clinical trials for diabetic peripheral neuropathic pain.
Verwenden
Mirogabalin is a two alpha2delta ligand which is investigated for the treatment of peripheral neuropathic pain, postherpetic neuralgia and fibromyalgia, showing promising results in patients with diabetic peripheral neuropathy.
Trademarks
Mirogabalin (brand name Tarlige; developmental code name DS-5565) is a gabapentinoid medication developed by Daiichi Sankyo.
Mirogabalin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Mirogabalin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 191)Lieferanten
- Mirogabalin
- [(1R,5S,6S)-6-(Aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid
- A200-0700
- DS5565;A200-0700
- 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid
- MIROGABALIN; DS-5565
- DS 5565;DS-5565;DS5565
- Bicyclo[3.2.0]hept-3-ene-6-acetic acid, 6-(aminomethyl)-3-ethyl-, (1R,5S,6S)-
- Miluobalin
- 2-((1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid
- Asapiprant
- DS5565
- Mirogabalin HCl
- Milobarin
- mirobalin
- Mirogabalin free base
- Mirogabalin Impurity
- 1138245-13-2
- API
- 1138245-13-2