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Eliglustat hemitartrate

Eliglustat hemitartrate Struktur
928659-70-5
CAS-Nr.
928659-70-5
Englisch Name:
Eliglustat hemitartrate
Synonyma:
GENZ112638;Eligluhemitartrate;Eliglustat (Tartrate);Eliglustat (hemitartrate);Eliglustat tartrate (Genz-112638);GENZ-112638;GENZ 112638;GENZ112638;Eliglustat hemitartrate(Genz-99067);Eliglustat hemitartrate (Genz-112638);Eliglustat (Tartrate),Eliglustat tartrate;Genz112638,Inhibitor,Eliglustat,Genz 112638,inhibit,Eliglustat hemitartrate
CBNumber:
CB22667944
Summenformel:
C50H78N4O14
Molgewicht:
959.17272
MOL-Datei:
928659-70-5.mol

Eliglustat hemitartrate Eigenschaften

Schmelzpunkt:
>133°C (dec.)
storage temp. 
-20°C Freezer, Under inert atmosphere
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
White
InChIKey
KUBARPMUNHKBIQ-VTHUDJRQSA-N

Sicherheit

Eliglustat hemitartrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Eliglustat tartrate, developed and marketed by Genzyme Corporation (a subsidiary of Sanofi), was approved by the US FDA in August 2014 for the treatment of nonneuropathic (type 1) Gaucher disease (GD1) in both treatment-naive and treatment-experienced adult patients. It is the first oral treatment to be approved for first-line use in patients with Gaucher disease type 1, which is a rare lysosomal storage disease characterized by accumulation of lipid glucosylceramide (GL-1) due to insufficient production of the enzyme glucosylceramidase. Clinical complications include hepatosplenomegaly, anemia, thrombocytopenia, and bone involvement. Eliglustat is a specific inhibitor of glucosylceramide synthase with an IC50 of 10 ng/mL and acts as substrate reduction therapy for GD1; it has demonstrated non-inferiority to enzyme replacement therapy, which is the current standard of care, in Phase III trials.

Verwenden

Eliglustat Tartrate functions as an oral agent for treatment of Gaucher disease type 1, and lysosomal storage disorders in human. It also inhibits UDP-glucosylceramide synthase in mice thereby preventing Gaucher disease-associated with B-cell malignancy.

Definition

ChEBI: A tartrate that is the hemitartrate salt of eliglustat. A ceramide glucosyltransferase inhibitor used (as its tartrate salt) for treatment of Gaucher's disease.

in vitro

Eliglustat tartrate (Eliglustat hemitartrate) shows good potency with an IC50 of 24 nM and specificity against the target enzyme. Incubating K562 or B16/F10 cells for 72 h with increasing amounts of Genz-112638 (0.6-1000 nM) results in a dose-dependent reduction of both GM1 and GM3 cell surface levels. The mean IC50 value for inhibiting the cell surface presentation of GM1 in K562 cells was 24 nM (range 14-34 nM), and that for GM3 in B16/F10 cells was 29 nM (range 12-48 nM).

Eliglustat hemitartrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Eliglustat hemitartrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 100)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
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ivan@atkchemical.com China 32956 60
BOC Sciences
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career henan chemical co
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TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Shanxi Xuanran Import and Export Trade Co., Ltd.
+8617735180244
mike_yan@xuanranglobal.com CHINA 4017 58
sgtlifesciences pvt ltd
+8617013299288
dj@sgtlifesciences.com China 12373 58
InvivoChem
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sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58

928659-70-5()Verwandte Suche:


  • Eliglustat (Tartrate)
  • Eliglustat (hemitartrate)
  • Eliglustat hemitartrate(Genz-99067)
  • GENZ112638
  • (2R,3R)-2,3-Dihydroxysuccinic acid - N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1-pyrrolidinyl)-2-propanyl]octanamide (1:2)
  • N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide,(2R,3R)-2,3-dihydroxybutanedioic Acid
  • Eliglustat hemitartrate (Genz-112638)
  • GENZ-99067;GENZ99067;GENZ 99067;GENZ-112638;GENZ112638;GENZ 112638;ELIGLUSTAT TARTRATE
  • Eliglustat tartrate (Genz-112638)
  • GENZ-112638;GENZ 112638;GENZ112638
  • Eliglustat (Tartrate),Eliglustat tartrate
  • Genz112638,Inhibitor,Eliglustat,Genz 112638,inhibit,Eliglustat hemitartrate
  • N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)octanamide ((2R,3R)-2,3-dihydroxysuccinate)(2:1)
  • Eligluhemitartrate
  • 928659-70-5
  • C50H78N4O14
  • 1
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