JW55
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- CAS-Nr.
- 664993-53-7
- Englisch Name:
- JW55
- Synonyma:
- JW55;CS-1095;JW 55; JW-55;JW 55, >=98%;Tankyrase1/2 Inhibitor IV, JW55;Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
- CBNumber:
- CB22645126
- Summenformel:
- C25H26N2O5
- Molgewicht:
- 434.48
- MOL-Datei:
- 664993-53-7.mol
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JW55 Eigenschaften
- Siedepunkt:
- 572.6±50.0 °C(Predicted)
- Dichte
- 1.235±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- DMSO: soluble15mg/mL, clear
- pka
- 12.41±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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JW55 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC
50s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC
50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells
in vitro.
Verwenden
JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.
JW55 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
JW55 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 115)Lieferanten
- JW55
- N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide
- N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE
- N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
- JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
- JW 55, >=98%
- N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid
- Tankyrase1/2 Inhibitor IV, JW55
- Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem
- JW 55; JW-55
- CS-1095
- 2-Furancarboxamide, N-[4-[[[[tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-
- 664993-53-7
- Inhibitors
- Amines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
