MF-63 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Microsomal prostaglandin E₂ synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE₂. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC₅₀ = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig mPGES-1 (IC₅₀ = 0.9 nM) but not mouse or rat mPGES-1. In guinea pigs or in mice expressing human mPGES-1, MF63 prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain. It does not produce the gastrointestinal toxicity that is caused by non-selective COX inhibitors, although it markedly suppresses PGE₂ synthesis in the stomach.

Verwenden

MF 63 is a microsomal prostaglandin E2 synthase-1 (mPGES-1) the final enzyme in the synthesis of PGE2. Prevents LPS-induced hyperglasia. Anti-inflammatory, analgesic, anti-cancer agent.

MF-63 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MF-63 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6005	61

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• MF-63
• 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile
• 2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile
• 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-Benzenedic
• MF 63; MF-63
• CS-2773
• 1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-
• 2-(9-Chloro-1H-phenanthro[9, 10-d]imidazol-2-yl)benzene-1, 3-dicarbonitrile
• 892549-43-8
• C23H11ClN4