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N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Struktur
925434-55-5
CAS-Nr.
925434-55-5
Englisch Name:
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Synonyma:
SRT1720 free base/ STR1720 HCl salt;SRT1720 - CAS 925434-55-5 - Calbiochem;N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide;N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide;2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-;N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide
CBNumber:
CB22489951
Summenformel:
C25H23N7OS
Molgewicht:
469.56
MOL-Datei:
925434-55-5.mol

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Eigenschaften

Schmelzpunkt:
221℃
Dichte
1.46
storage temp. 
-20C
L?slichkeit
DMSO:5.0(Max Conc. mg/mL);10.65(Max Conc. mM)
Aggregatzustand
Yellow solid
pka
11.19±0.70(Predicted)
Farbe
Light yellow to yellow

Sicherheit

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 μM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9 μM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748).

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

tert-butyl 4-((6-(2-aMinophenyl)iMidazo[2,1-b]thiazol-3-yl)Methyl)piperazine-1-carboxylate 6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE-3-CARBOXYLIC ACID (6-(2-nitrophenyl)iMidazo[2,1-b]thiazol-3-yl)Methyl Methanesulfonate 6-(2-NITRO-PHENYL)-IMIDAZO[2,1-B]THIAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE 2-QUINOXALINECARBONYL CHLORIDE 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 2-Bromo-2'-nitroacetophenone

Downstream Produkte

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 65)Lieferanten
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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Alchem Pharmtech,Inc. 		8485655694
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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InvivoChem 		+1-708-310-1919 +1-13798911105
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RR Scientific LLC 		+86-13917743231
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TargetMol Chemicals Inc.
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Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
  • N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
  • N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide
  • 2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-
  • SRT1720 free base/ STR1720 HCl salt
  • Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide
  • SRT1720 - CAS 925434-55-5 - Calbiochem
  • N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide
  • 925434-55-5
  • 5434-55-5
  • C25H23N7OS
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