SENEGENIN
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- CAS-Nr.
- 2469-34-3
- Englisch Name:
- SENEGENIN
- Synonyma:
- SENEGIN;SENEGENIN;Tenuigenin;Tenuifgenin;Senegenin-RM;Tenuifolic acid;Senegenin (6CI);Senegenin, >=98%;12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid;12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid
- CBNumber:
- CB2222527
- Summenformel:
- C30H45ClO6
- Molgewicht:
- 537.13
- MOL-Datei:
- 2469-34-3.mol
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SENEGENIN Eigenschaften
- Schmelzpunkt:
- 290-292℃
- alpha
- D +19° (c = 0.70 in ethanol)
- Siedepunkt:
- 674.1±55.0 °C(Predicted)
- Dichte
- 1.28
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear
- pka
- 4.27±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| RTECS-Nr. |
RC8815000 |
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| Toxizit?t |
LD50 intraperitoneal in mouse: 3mg/kg |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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SENEGENIN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tenuigenin is a triterpenoid sapogenin that has been found in
P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal
S. aureus-induced pneumonia.
Verwenden
Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.
SENEGENIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SENEGENIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 179)Lieferanten
2469-34-3()Verwandte Suche:
Hellebrin
α,2,2,6-Tetramethylcyclohexen-1-butyraldehyd
3,3,5,5-Tetramethylcyclohexanol
Dimethylcyclohex-3-en-1-carbaldehyd
Tridecandisaeure
2-Decyltetradecanol
1-Chloroctadecan
2,2,4,6,6-Pentamethylhept-3-en
Chloricosan
Undecandisaeure
1-Methyl-4-(4-methylpentyl)cyclohex-3-en-1-carbaldehyd
Tricosansure
Fettsuren, C16-18- und C18-ungesttigt
1-Chlorhexadecan
- SENEGENIN
- SENEGIN
- 28-dioicacid,12-(chloromethyl)-2-beta,3-beta-dihydroxy-27-noro-13-ene-2
- 27-Norolean-13-ene-23,28-dioicacid, 12-(chloromethyl)-2,3-dihydroxy-, (2β,3β,4α,12α)-
- Tenuigenin
- 12α-(Chloromethyl)-2β,3β-dihydroxy-27-nor-5α-olean-13-ene-23,28-dioic acid
- 12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid
- Tenuifolic acid
- (2beta,3beta,4alpha,12alpha)-12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid
- 12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid
- Senegenin, >=98%
- 13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid
- Tenuifgenin
- (2S,3R,4S,4aR,6aR,8aS,12aS,13S,14aR,14bR)-13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid
- 13-(Chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydro-4,8a(1H)-picenedicarboxylic acid
- Senegenin (6CI)
- Senegenin-RM
- 2469-34-3
- C30H45ClO6
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
