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DMT-2′O-Methyl-rC(ac) Phosphoramidite

DMT-2′O-Methyl-rC(ac) Phosphoramidite Struktur
199593-09-4
CAS-Nr.
199593-09-4
Englisch Name:
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Synonyma:
(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Cytidine Impurity 14;2’-OMe -dC(Ac) Amidite;N4-Ac-5'-O-DMT-2'-OMe-C-CE;N4-Ac-5'-O-DMT-2'-OMe-C-CE;2'-OMe-Ac-C Phosphoramidite;2'-OMe-N-Ac CytidineAmidite;Ac-2'-Ome-rC Phosphoramidite;2'-OMe-Ac-C Phosphoramidite;2'-OMe-C(Ac) Phosphoramidite
CBNumber:
CB21871625
Summenformel:
C42H52N5O9P
Molgewicht:
801.86
MOL-Datei:
199593-09-4.mol

DMT-2′O-Methyl-rC(ac) Phosphoramidite Eigenschaften

Schmelzpunkt:
102 - 104°C
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
powder
pka
10.18±0.20(Predicted)
Farbe
white to off-white
InChIKey
WNWUMIPFLOKTEZ-UAQIPLLRSA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,39,42,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 24/25
WGK Germany  3
HS Code  29349990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

DMT-2′O-Methyl-rC(ac) Phosphoramidite Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

Allgemeine Beschreibung

DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
High yield of crude oligonucleotides
Compatible with DNA synthesis
Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

DMT-2′O-Methyl-rC(ac) Phosphoramidite Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DMT-2′O-Methyl-rC(ac) Phosphoramidite Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 161)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhu Nuowei chemistry Co., Ltd.
+86-0553-2911116-802 +undefined17756524438
sales1@nuowei-chem.com China 1638 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18751 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10311 58
Yunbio Tech Co.,Ltd.
+86-010-60605551 +86-18046518538
yunbiochem@126.com China 321 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9636 58

199593-09-4()Verwandte Suche:


  • 2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite
  • -5-(4-Acetamido-2-oxopyrimidin-1(2H)
  • 2'-OMe-Ac-C Phosphoramidite
  • 2’-O-Methyl-rC(N-Ac)Phosphoramidite
  • 5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-DMT-2'-OMe-rC(N-Ac) Phosphoramidite
  • N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
  • DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • Ac-2'-Ome-rC Phosphoramidite
  • 2'-OMe-Ac-rC -CE Phosphoramidite
  • N4-acetyl-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Cytidine-3'-CE-Phosphoramidite
  • 2'-OMe-Ac-C Phosphoramidite (~90%)
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 2'-OMe-C(Ac) Phosphoramidite
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP
  • 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • N4-ACETYL-5-O-DMTr-2-O-METHYLCYTIDINE-3-O- CE-AMIDITE
  • 5'-O-DMT-2'-OMe-Ac-C-CE-Phosphoramidite
  • (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 5'-O-DMT-N4-Acetyl-2'-O-methylcytidine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite
  • DMT-2-O-ME-C-CE Phosphoramidite
  • "DMT-2'-O-Me-dC(Ac) Phosphoramidite"
  • N4-Ac-5'-O-DMT-2'-OMe-C-CE
  • DMT-2’-OMe-C(Ac)-CE Phosphoramidite
  • 2'-OMe-N-Ac Cytidine?Amidite
  • DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite
  • 2’-OMe -dC(Ac) Amidite
  • 5'-ODMT-2'-OMe-N-Ac Cytidine-3'-OCEPA
  • 2'-OMe-Ac-C Phosphoramidite
  • DMT-2'-O-Me-C(Ac)-CE Phosphoramidite
  • N4-Ac-5'-O-DMT-2'-OMe-C-CE
  • 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite
  • 2'-OMe-C(Ac)-CE-Phosphoramidite
  • 2'-OMe-Ac-C CE Phosphoramidite
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 2'-OMe-rC(Ac)Phosphoramidite
  • N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
  • 2'-OMe-N-Ac CytidineAmidite
  • DMT-2'O-METHYL-RC(AC) PHOSPHORAMIDITE
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
  • Cytidine Impurity 14
  • 199593-09-4
  • C42H52N5O9P
  • Amidite
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