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Calhex 231

Calhex 231 Struktur
652973-93-8
CAS-Nr.
652973-93-8
Englisch Name:
Calhex 231
Synonyma:
Calhex 231;Calhex-231 (Calhex231);Calhex 231 hydrochloride;4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]benzamide;Benzamide, 4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-;4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
CBNumber:
CB21565173
Summenformel:
C25H27ClN2O
Molgewicht:
406.95
MOL-Datei:
652973-93-8.mol

Calhex 231 Eigenschaften

Schmelzpunkt:
53-55°C
storage temp. 
-20°C Freezer
L?slichkeit
DMSO: soluble15mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige
CAS Datenbank
652973-93-8

Sicherheit

WGK Germany  3

Calhex 231 Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White Solid

Verwenden

Calhex 231 hydrochloride has been used:
  • as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats
  • to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)
  • to test its effect on acoustic response bias in zebrafish
  • in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )

Biochem/physiol Actions

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC50 of 0.36 μM.

Calhex 231 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Calhex 231 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]benzamide
  • Calhex 231
  • Calhex 231 hydrochloride
  • 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
  • Calhex-231 (Calhex231)
  • Benzamide, 4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-
  • 652973-93-8
  • C25H27ClN2O
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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