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Physostigminsalicylat

PHYSOSTIGMINE SALICYLATE Struktur
57-64-7
CAS-Nr.
57-64-7
Bezeichnung:
Physostigminsalicylat
Englisch Name:
PHYSOSTIGMINE SALICYLATE
Synonyma:
ESERINE SALICYLATE;Physostigmine-d3 salicylate;ar-44;tl-1380;CCRIS 3405;Isopto Eserine;EINECS 200-343-8;physostolsalicylate;Physostigminsalicylat;ESERINE SALICYLATE(RG)
CBNumber:
CB2146890
Summenformel:
C22H27N3O5
Molgewicht:
413.47
MOL-Datei:
57-64-7.mol

Physostigminsalicylat Eigenschaften

Schmelzpunkt:
181-183 °C
storage temp. 
-20°C
L?slichkeit
DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
pka
pKa 1.96/8.08(H2O,t =15) (Uncertain)
Aggregatzustand
Solid
Farbe
White to yellow
Merck 
7384
BRN 
3900576
InChIKey
HZOTZTANVBDFOF-DPKVYHSMNA-N
SMILES
C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|
CAS Datenbank
57-64-7(CAS DataBase Reference)
EPA chemische Informationen
Physostigmine salicylate (57-64-7)

Sicherheit

Kennzeichnung gef?hrlicher T+
R-S?tze: 26/28
S-S?tze: 25-45
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS-Nr. TJ2450000
HazardClass  6.1(a)
PackingGroup  II
HS Code  2939800000
Toxizit?t LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)

Physostigminsalicylat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R26/28:Sehr giftig beim Einatmen und Verschlucken.

S-S?tze Betriebsanweisung:

S25:Berührung mit den Augen vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Chemische Eigenschaften

solid

Verwenden

Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet

Allgemeine Beschreibung

The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.

Reaktivit?t anzeigen

Behaves as a weak acid in solution.

Health Hazard

PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.

Brandgefahr

When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides.

Sicherheitsprofil

Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.

Physostigminsalicylat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Physostigminsalicylat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 104)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9636 58
Kindchem(Nanjing)Co.,Ltd
+86-025-025-85281586 +8618651653755
sales@kindchem.cn China 1226 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Dorne Chemical Technology co. LTD
+86-86-13583358881 +8618560316533
Ethan@dornechem.com China 3097 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Finetech Industry Limited
+86-27-87465837 +8618971612321
info@finetechnology-ind.com China 9639 58

57-64-7(Physostigminsalicylat)Verwandte Suche:


  • PHYSOSTIGMINE SALICYLATE SALT
  • 2-hydroxy-,compd.with(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci
  • ar-44
  • ESERINE MONOSALICYLATE
  • ESERINE SALICYLATE SALT
  • ESERINE SALICYLATE 99.9%
  • Physostigmine monosalicylate
  • Physostigmine salicylate (Eserine salicylate)
  • Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1)
  • PHYSOSTIGMINESALICYLATE,USP
  • ESERINE SALICYLATE(RG)
  • Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI)
  • Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
  • Isopto Eserine
  • Physostigmine salicylate (6CI)
  • Physostigmine, monosalicylate (8CI)
  • Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, mono(2-hydroxybenzoate) (salt) (9CI)
  • Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, mono(2-hydroxybenzoate) (salt)
  • Salicylic acid, compd. with physostigmine (1:1) (8CI)
  • Physostigminsalicylat
  • Benzoicacid,2-hydroxy-,cpmpd,with(3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indo1-5-ylmethylcarbamateester(1:1)
  • physostigmine,[salicylate(1:1)]
  • physostigmine,salicylate(1:1)
  • physostolsalicylate
  • salicylicacid,compd.withphysostigmine(1:1)
  • tl-1380
  • trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1)
  • Physostigmine Salicylate (200 mg)
  • (3aS,8aR)-1,3a,8-triMethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl MethylcarbaMate 2-hydroxybenzoate
  • Eserine salicylate salt >=97.0% (N)
  • Physostigmine salicylate CRS
  • (?)-Physostigmine (salicylate)
  • PHYSOSTIGMINE SALICYLATE INJECTION
  • PHYSOSTIGMINE SALICYLATE USP/EP/BP
  • Physostigmine Salicylate (1537003)
  • ESERINE SALICYLATE
  • Physostigmine-d3 salicylate
  • inhibit,Eserine,antidote,Physostigmine,blood-brain,Physostigmine Salicylate,Alzheimer's,Cholinesterase (ChE),Inhibitor,barrier
  • CCRIS 3405
  • EINECS 200-343-8
  • Physostigmine Salicylate
  • 57-64-7
  • C22H27N3O5
  • C15H21N3O2C7H6O3
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • Alkaloids
  • Indole Alkaloids
  • Alphabetic
  • Drug Standards
  • Chromatography
  • EQ - EZ
  • Forensic and Veterinary Standards
  • Inhibitors
  • ANTILIRIUM
  • Alkaloids
  • Biochemistry
  • Indole Alkaloids
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