(S)-(+)-3-Hydroxytetrahydrofuran
|
|
|
- CAS-Nr.
- 86087-23-2
- Englisch Name:
- (S)-(+)-3-Hydroxytetrahydrofuran
- Synonyma:
- (S)-TETRAHYDROFURAN-3-OL;(S)-3-HYDROXYTETRAHYDROFURAN;(3S)-oxolan-3-ol;(3S)-Tetrahydrofuran-3-ol;(S)-(-)-3-HYDROXY TETRAHYDRO FURAN;S-HTHF;Oxolane-3β-ol;(S)-Hydroxy THF;Afatinib intermediate;S-3- Hydroxytetrafuran
- CBNumber:
- CB2142463
- Summenformel:
- C4H8O2
- Molgewicht:
- 88.11
- MOL-Datei:
- 86087-23-2.mol
|
(S)-(+)-3-Hydroxytetrahydrofuran Eigenschaften
- alpha
- 18.5 º (c=2 MeOH)
- Siedepunkt:
- 80 °C/15 mmHg (lit.)
- Dichte
- 1.103 g/mL at 25 °C (lit.)
- Dampfdruck
- 47Pa at 25℃
- Brechungsindex
- n20/D 1.45(lit.)
- Flammpunkt:
- 175 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform, Methanol (Slightly)
- pka
- 14.49±0.20(Predicted)
- Aggregatzustand
- Liquid
- Farbe
- Clear colorless to pale yellow
- Wichte
- 1.11
- Optische Aktivit?t
- [α]20/D +17.5°, c = 2.4 in methanol
- Wasserl?slichkeit
- soluble
- BRN
- 4652609
- Stabilit?t:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- XDPCNPCKDGQBAN-BYPYZUCNSA-N
- LogP
- -0.784 at 22℃ and pH6.8
- Oberfl?chenspannung
- 72mN/m at 1g/L and 25℃
- CAS Datenbank
- 86087-23-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
|
|
| R-S?tze: |
36/37/38 |
|
|
| S-S?tze: |
26-37/39 |
|
|
| RIDADR |
NA 1993 / PGIII |
|
|
| WGK Germany |
3 |
|
|
| HS Code |
29321900 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
(S)-(+)-3-Hydroxytetrahydrofuran Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.
Chemische Eigenschaften
Colourless Liquid
Verwenden
(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.
Synthese
(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows：To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.
(S)-(+)-3-Hydroxytetrahydrofuran Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-(+)-3-Hydroxytetrahydrofuran Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 736)Lieferanten
86087-23-2()Verwandte Suche:
- (S)-(+)-TETRAHYDRO-3-FURANOL
- (S)-(+)-3-HYDROXY TETAHYDRO FURAN
- (2S)-1,4-Epoxy-2-hydroxybutane, (3S)-Tetrahydrofuran-3-ol, (3S)-Oxolan-3-ol
- Afatinib intermediate B
- (S)-(+)-3-Hydroxytetrahydrofuran, ee: 95%
- Afatinib intermediate
- (S)-(+)-3-HydroxytetrahydrofuranZ
- (S)-(+)-3-Hydroxytetrahydrofuran 99%
- (S)-(+)-3-HYDROXYTETRAHYDROFURAN
- (S)-(+)-3-HYDROXYTETRAHYDROFURANE
- 3-FURANOL, TETRAHYDRO-, (S)
- (S)-(+)-3-HYDROXYTETRAHYDROFURAN, 99% (9
- S-(+)-3-HYDROXYTETRAHYDROFURAN 98+%
- (S)-(+)-3-HYDOXY TETAHYDRO TETRAHYDRO FURAN
- (S)-3-Hydroxyterthydrofurane
- S-HYDROXYTETRAHYDROFURAN
- S-(+)-3-Hydroxytetrahydofuran
- (3S)-Tetrahydrofuran-3β-ol
- Oxolane-3β-ol
- (S)-(+)-3-Hydroxytetrahydrofuran,99%
- (S)-(+)-tetrahyro-3-furanol
- (S)-(+)-3-Hydroxytetrahydrofuran ,98% [ee:95%]
- (2S)-2-Hydroxy-1,4-epoxybutane
- (3S)-3-Hydroxytetrahydrofuran
- (S)-(+)-3-Hydroxytetrahydrofuran, 98%
colorless liquid
- (S)-(+)-3-Hydroxytetrahydrofuran, 98%, ee: 95%
- (3S)-(+)-3-Hydroxytetrahydrofuran 97+%
- (S)-(+)-3-HYDROXYTETRAHYDROFURAN, (9
- (S)-(+)-3-Hydroxy-1,2,3,4-tetrahydrofuran
- S-3-hydroxytetrahydrofur
- (S)-3-hydroxytetyrahydrofurane
- S-3- Hydroxytetrafuran
- 3-Furanol, tetrahydro-, (3S)-
- (S)-(+)-3-HYDROXYTETRAHYDROFURAN (CAS NO.86087-23-2)
- (S)-Hydroxy THF
- (3S)-Tetrahydrofuran-3-ol,(3S)-Oxolan-3-ol
- (+)-3-Hydroxy-1,2,3,4-Tetrahydrofuran
- (S)-TETRAHYDROFURAN-3-OL
- (S)-(-)-3-HYDROXY TETRAHYDRO FURAN
- (3S)-oxolan-3-ol
- (S)-3-HYDROXYTETRAHYDROFURAN
- (3S)-Tetrahydrofuran-3-ol
- Empagliflozin Impurity 100
- (S)-3-hydroxytetyrahydrofuran
- (+)-3-Hydroxytetrahydrofuran
- S-HTHF
- 2,4-Dichlorobenzyl Alcohol Impurity 10
- 86087-23-2
- 86087-23-3
- ALCOHOL
- Simple Alcohols (Chiral)
- Chiral Building Blocks
- Heterocyclic Building Blocks
- Furans
- Asymmetric Synthesis
- Afatinib intermediate
- Chiral Building Blocks
- Simple Alcohols (Chiral)
