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SANT-1

SANT-1 Struktur
304909-07-7
CAS-Nr.
304909-07-7
Englisch Name:
SANT-1
Synonyma:
SANT-1;CS-1685;SANT1 10MG;SANT1;SANT 1;SANT-1 USP/EP/BP;SANT-1; SANT1;SANT 1;SANT-1 - CAS 304909-07-7 - Calbiochem;SANT-1 (This product is only available in Japan.);SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit;(E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
CBNumber:
CB2141123
Summenformel:
C23H27N5
Molgewicht:
373.49
MOL-Datei:
304909-07-7.mol

SANT-1 Eigenschaften

Schmelzpunkt:
104-106°C
Siedepunkt:
547.4±50.0 °C(Predicted)
Dichte
1.13±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Soluble in DMSO with warming
Aggregatzustand
White solid
pka
7.35±0.10(Predicted)
Farbe
White to off-white
Sensitive 
Moisture & Light Sensitive
CAS Datenbank
304909-07-7

Sicherheit

WGK Germany  3

SANT-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. SANT 1 is a potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC50 = 20 nM). It counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO. SANT 1 targets inactive SMO while it is in the cytoplasm, before it relocates to the primary cilium and is activated. Through antagonism of SMO, SANT 1 represses Gli-mediated transcription in a variety of cell types.

Chemische Eigenschaften

Pale Yellow Solid

Verwenden

Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death.

Biologische Aktivit?t

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K D = 1.2 nM). Inhibits smoothened agonist effects with an IC 50 of 20 nM (in Shh-LIGHT2 cells).

SANT-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


SANT-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 87)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 96815 76

  • N-[(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHYLENE]-4-(PHENYLMETHYL)-1-PIPERAZINAMINE
  • SANT-1
  • (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
  • 1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-
  • (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
  • SANT1 10MG
  • SANT1;SANT 1
  • SANT-1 - CAS 304909-07-7 - Calbiochem
  • CS-1685
  • SANT-1; SANT1;SANT 1
  • SANT-1 (This product is only available in Japan.)
  • N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
  • SANT-1 USP/EP/BP
  • SANT1,Smoothened,Hedgehog,Inhibitor,Smo,SANT-1,inhibit
  • 304909-07-7
  • C23H27N5
  • Lipid signaling
  • Inhibitors
  • All Inhibitors
  • API
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