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Docarpamine

Docarpamine Struktur
74639-40-0
CAS-Nr.
74639-40-0
Englisch Name:
Docarpamine
Synonyma:
TA 870;TA-8704;Tanadopa;Docarpamine;3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine;4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate;(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide;Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester;Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-;Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
CBNumber:
CB21178560
Summenformel:
C21H30N2O8S
Molgewicht:
470.54
MOL-Datei:
74639-40-0.mol

Docarpamine Eigenschaften

Schmelzpunkt:
85-90°; mp 105-108° (Nishiyama, 1992)
alpha 
D20 -15.6° (c = 2 in methanol)
Siedepunkt:
731.0±60.0 °C(Predicted)
Dichte
1.222±0.06 g/cm3(Predicted)
pka
14.51±0.46(Predicted)

Sicherheit

Toxizit?t LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992)

Docarpamine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA1) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.

Verwenden

Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.

Docarpamine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Docarpamine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 11)Lieferanten
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TLC Pharmaceutical Standards Ltd. 18012923235
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  • Docarpamine
  • Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester
  • Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-
  • TA 870
  • Tanadopa
  • (S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide
  • 3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine
  • TA-8704
  • Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
  • 4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate
  • 74639-40-0
  • C21H30N2O8S
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