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NS-398

NS-398 Struktur
123653-11-2
CAS-Nr.
123653-11-2
Englisch Name:
NS-398
Synonyma:
NS NS;NS-398;CS-2231;NS-398 98%;Taisho NS 398;NS-398 (NS 398;NS-398 USP/EP/BP;glycolysis inhibitor;mitochondrial complex I inhibitor;mitochondrial complex III inhibitor
CBNumber:
CB1754593
Summenformel:
C13H18N2O5S
Molgewicht:
314.36
MOL-Datei:
123653-11-2.mol

NS-398 Eigenschaften

Schmelzpunkt:
124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Siedepunkt:
490.6±55.0 °C(Predicted)
Dichte
1.377±0.06 g/cm3(Predicted)
RTECS-Nr.
PB0473500
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMSO: >5 mg/mL
Aggregatzustand
solid
pka
6.33±0.10(Predicted)
Farbe
off-white

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3
HS Code  2935.90.9500

NS-398 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC50 values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.

Verwenden

NS-398 is a selective Cox-2 inhibitor neuroprotective agent.

Definition

ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.

Biologische Aktivit?t

Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .

NS-398 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


NS-398 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 152)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 970 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58
Henan Alfa Chemical Co., Ltd

China 10947 58

123653-11-2()Verwandte Suche:


  • NS-398
  • N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE
  • NS-398 98%
  • N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide
  • Taisho NS 398
  • CS-2231
  • NS-398 (NS 398
  • NS-398 - CAS 123653-11-2 - Calbiochem
  • NS 398; NS398; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANE SULFONAMIDE
  • NS NS
  • Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]-
  • NS-398 USP/EP/BP
  • Inhibitor,inhibit,NS-398,NS 398,COX,Cyclooxygenase
  • mitochondrial complex I inhibitor
  • mitochondrial complex III inhibitor
  • glycolysis inhibitor
  • 123653-11-2
  • 123652-11-2
  • Cyclooxygenase (COX) Enzymes
  • Cyclooxygenase Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Biochemicals and Reagents
  • Cell Signaling Enzymes
  • BioChemical
  • Application Index
  • Signalling
  • Lipid signaling
  • NF-κB Signaling
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