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Roxithromycin

Roxithromycin Struktur
80214-83-1
CAS-Nr.
80214-83-1
Englisch Name:
Roxithromycin
Synonyma:
Roxid;Rulid;Roxithromycin Solution, 100ppm;Brilid;Overal;RU 965;Surlid;Assoral;Forilin;biaxsig
CBNumber:
CB1707342
Summenformel:
C41H76N2O15
Molgewicht:
837.05
MOL-Datei:
80214-83-1.mol

Roxithromycin Eigenschaften

Schmelzpunkt:
111-118?C
alpha 
D25 -77.5 ±2° (c = 0.45 in chloroform)
Siedepunkt:
864.7±75.0 °C(Predicted)
Dichte
1.25±0.1 g/cm3(Predicted)
Flammpunkt:
>110°(230°F)
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
chloroform: soluble10mg/mL
pka
pKa 9.27±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)
Aggregatzustand
powder
Farbe
White to off-white
Wasserl?slichkeit
Soluble in water to 18µg/ml
Merck 
14,8276
InChIKey
RXZBMPWDPOLZGW-HEWSMUCTSA-N
CAS Datenbank
80214-83-1
EPA chemische Informationen
Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime], (9E)- (80214-83-1)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 26-24/25
WGK Germany  3
RTECS-Nr. KF4990000
HS Code  29415000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Roxithromycin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Roxithromycin, an oxime ether derivative of erythromycin, is a new macrolide antibiotic of high potency and long duration. Its in v i m activity spectrum is similar to that of erythromycin, but is superior to the latter against Legionella, Mycoplasma and Chlamydia.

Chemische Eigenschaften

White Solid

Verwenden

Roxithromycin was one of the new generation erythromycins introduced in the 1980s. Improved acid stability was achieved by converting the 9-keto group to the more stable oxime and alkylation of the oxime to provide the methoxyethoxymethyl ether oxime. In vivo, roxithromycin exhibits higher tissue levels and a longer half-life while being slightly less potent than erythromycin in vitro.

Antimicrobial activity

Activity against common pathogens is comparable to that of erythromycin. It is active against L. monocytogenes, C. jejuni, H. ducreyi, G. vaginalis, Bord. pertussis, C. diphtheriae, B. burgdorferi, H. pylori, the M. avium complex, Chlamydia spp., and U. urealyticum.

Pharmazeutische Anwendungen

A semisynthetic derivative of erythromycin A formulated for oral use.

Nebenwirkungen

It is generally well tolerated, adverse effects being described in 3–4% of patients, mostly gastrointestinal disturbance (abdominal pain, nausea and diarrhea). Headache, weakness, dizziness, rash and reversible changes in liver function tests and increased eosinophils and platelets have also been described.

Roxithromycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Roxithromycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 582)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Henan Suikang Pharmaceutical Co.,Ltd.
+86-18239973690 +86-18239973690
sales@suikangpharm.com China 311 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 456 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58

80214-83-1()Verwandte Suche:


  • ROXITHROMYCIN
  • Roxithromycin CP2000
  • ERYTHROMYCIN 9-(-O-[2-METHOXYETHOXY]METHYLOXIME)
  • ERYTHROMYCIN, 9-[O-[(2-METHOXYETHOXY)METHYL]OXIME], (9E)-
  • Roxithromycin EP
  • RoxithromycinEp/Bp/CpC41H76N2O15
  • RoxithromycinC41H76N2O15
  • (9E)-9-[O-[(2-Methoxyethoxy)methyl]oxime] Erythromycin
  • Assoral
  • Roxl-150
  • Roxithromycin (Roxl-150)
  • 10% water-soluble roxithromycin
  • Roxithromycin solution,1000ppm
  • ROM erythromycin(Water soluble)
  • 70% water-soluble roxithromycin
  • Brilid
  • Claramid
  • Forilin
  • Overal
  • Rossitrol
  • Rotramin
  • Roxeptin
  • Roxithromycin A
  • RU 28965
  • RU 965
  • Surlid
  • biaxsig
  • ROXITHROMYCIN,BP,EP
  • Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime], (9E)- (9CI)
  • 5-(3,4,6-Trideoxy-3-dimethylamino-beta-D-xylo-hexopyranosyloxy)-3-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-6,11,12-trihydroxy-9-(2-methoxyethoxy)methoxyimino-2,4,6,8,10,12-hexamethylpentadecan-13-olide
  • water-soluble roxithromycin70%
  • aaram.D.Forilin
  • 9-[O-(2-Methoxyethoxy)methyloxime]erythromycin
  • 9-Deoxo-9-[(2-methoxyethoxy)methoxyimino]erythromycin
  • 9-Deoxo-9-[[(2-methoxyethoxy)methyl]oxyimino]erythromycin
  • Roxithromycin,Erythromycin 9-(-O-[2-methoxyethoxy]methyloxime)
  • (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(diMethylaMino)-3-hydroxy-6-Methyloxan-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-Methoxy-4,6-diMethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexaMethyl-10-(2,4,7-trioxa-1-azaoctan-1-yl
  • RoxithroMycin API
  • Roxithromycin id
  • (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[4-(dimethylamino)-3-hydroxy-6-methyl-2-oxanyl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyl-2-oxanyl)oxy]-10-(2-methoxyethoxymethoxy
  • (E)-roxithromycin
  • Roxithromycin CRS
  • Roxithromycin for system suitability CRS
  • (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-10-(((2-methoxyethoxy)methoxy)imino)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
  • Roxithromycin USP/EP/BP
  • Roxithromycin (1.0 mg/mL in Methanol)
  • (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-10-(((2-methoxyethoxy)met
  • Roxithromycin-13CD3
  • RoxithromycinQ: What is Roxithromycin Q: What is the CAS Number of Roxithromycin Q: What is the storage condition of Roxithromycin Q: What are the applications of Roxithromycin
  • Roxithromycin Solution, 100ppm
  • Roxid
  • Rulid
  • Oxithromycin
  • Roxithromycin in Methanol
  • C16860000 Roxithromycin
  • Roxithromycin 100 μg/ml Methanol
  • 80214-83-1
  • 80241-83-1
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