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Denbufylline

Denbufylline Struktur
57076-71-8
CAS-Nr.
57076-71-8
Englisch Name:
Denbufylline
Synonyma:
brl30892;DENBUFYLLINE;1,3-DI-N-BUTYL-7-(2'-OXOPROPYL)XANTHINE;7-Acetonyl-1,3-dibutyl-3,7-dihydro-1H-purine-2,6-dione;3,7-dihydro-1,3-dibutyl-7-(2-oxopropyl)-1h-purine-6-dione;3,7-dihydro-1,3-dibutyl-7-(2-oxopropyl)-1h-purine-2,6-dione;1,3-Dibutyl-3,7-dihydro-7-(2-oxopropyl)-1H-purine-2,6-dione;1H-Purine-2,6-dione, 1,3-dibutyl-3,7-dihydro-7-(2-oxopropyl)-
CBNumber:
CB1704523
Summenformel:
C16H24N4O3
Molgewicht:
320.39
MOL-Datei:
57076-71-8.mol

Denbufylline Eigenschaften

Schmelzpunkt:
98-100°C
Siedepunkt:
514.8±56.0 °C(Predicted)
Dichte
1.23±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
L?slichkeit
DMSO, Methanol
Aggregatzustand
Solid
pka
-0.17±0.70(Predicted)
Farbe
Off-White to Pale Beige
CAS Datenbank
57076-71-8

Sicherheit

Denbufylline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Denbufylline, a xanthine derivative and PDE4 inhibitor, has effects such as vasodilatation of cerebral vessels (Willette et al., 1997) and potent activation of the hypothalamic–pituitary–adrenal axis. PDE4 is one of the cyclic adenosine monophosphate (cAMP)–specic phosphodiesterases whose tissue distribution is important in pathologies related to the central nervous and immune systems. In experimental animals, denbufylline increases adrenocorticotropic hormone (ACTH), circulating corticosterone, luteinizing hormone, corticotrophin-releasing hormone, and cAMP content of the hypothalamic tissue, but is without effect on arginine vasopressin (Kumari et al., 1997). Treves and Korczyn (1999) studied patients with AD, mixed dementia, and VaD treated with denbufylline. No signicant differences were found in comparison with placebo for the treatment of AD or VaD, although patients who received denbufylline tended to improve their cognitive scores.

Chemische Eigenschaften

White Solid

Verwenden

A cell permeable xanthine derivatvie that acts as a selective inhibitor of phosphodiesterase IV (PDE IV). Possesses bronchodilatory properties. Displays negative inotropic effect by acting on a verapamil-sensitive site of the calcium channel in guinea pig ventricle apaillary muscle independently of its PDE inhibitory activity.

Denbufylline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Denbufylline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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57076-71-8()Verwandte Suche:


  • 3,7-dihydro-1,3-dibutyl-7-(2-oxopropyl)-1h-purine-2,6-dione
  • 3,7-dihydro-1,3-dibutyl-7-(2-oxopropyl)-1h-purine-6-dione
  • brl30892
  • 1,3-DI-N-BUTYL-7-(2'-OXOPROPYL)XANTHINE
  • DENBUFYLLINE
  • 1,3-Dibutyl-3,7-dihydro-7-(2-oxopropyl)-1H-purine-2,6-dione
  • 7-Acetonyl-1,3-dibutyl-3,7-dihydro-1H-purine-2,6-dione
  • 1H-Purine-2,6-dione, 1,3-dibutyl-3,7-dihydro-7-(2-oxopropyl)-
  • 57076-71-8
  • C16H24N4O3
  • Inhibitors
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