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4-IODO-6-PHENYLPYRIMIDINE

4-IODO-6-PHENYLPYRIMIDINE Struktur
41270-96-6
CAS-Nr.
41270-96-6
Englisch Name:
4-IODO-6-PHENYLPYRIMIDINE
Synonyma:
4-IPP;MIF Antagonist III, 4-IPP;4-IODO-6-PHENYLPYRIMIDINE;Pyrimidine, 4-iodo-6-phenyl-;4-IPP (4-Iodo-6-phenylpyrimidine);MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem;Inhibitor,osteoclastogenesis,4IPP,MIF,4-IPP,inhibit,4 IPP,RANKL,osteoblast
CBNumber:
CB1686643
Summenformel:
C10H7IN2
Molgewicht:
282.08
MOL-Datei:
Mol file

4-IODO-6-PHENYLPYRIMIDINE Eigenschaften

Siedepunkt:
380.2±30.0 °C(Predicted)
Dichte
1.728±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMSO: soluble10mg/mL (clear solution, warmed)
Aggregatzustand
powder
pka
-0.54±0.17(Predicted)
Farbe
white to beige
InChIKey
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-37/38-41
S-S?tze: 26-39
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

4-IODO-6-PHENYLPYRIMIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.

Biologische Aktivit?t

Inhibitor of macrophage migration inhibitor factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo . Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro .

Biochem/physiol Actions

4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.

4-IODO-6-PHENYLPYRIMIDINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-IODO-6-PHENYLPYRIMIDINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 52)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24727 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15839 69
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826
market@aladdin-e.com China 25003 65
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Struchem Co., Ltd. 0512-0512-63009836 15365350169
helen@struchem.com China 3984 60
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60

  • 4-IODO-6-PHENYLPYRIMIDINE
  • 4-IPP
  • MIF Antagonist III, 4-IPP
  • MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem
  • Pyrimidine, 4-iodo-6-phenyl-
  • 4-IPP (4-Iodo-6-phenylpyrimidine)
  • Inhibitor,osteoclastogenesis,4IPP,MIF,4-IPP,inhibit,4 IPP,RANKL,osteoblast
  • 41270-96-6
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