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Pomalidomide-PEG3-NH2 hydrochloride

Pomalidomide-PEG3-NH2 hydrochloride Struktur
2380273-75-4
CAS-Nr.
2380273-75-4
Englisch Name:
Pomalidomide-PEG3-NH2 hydrochloride
Synonyma:
HCl NH2-PEG3-CH2CO-Poma;Pomalidomide-PEG3-NH2 hydrochloride;P933620 Pomalidomide-amino-PEG3-NH2 hydrochloride;2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide hydrochloride
CBNumber:
CB14846366
Summenformel:
C21H27ClN4O8
Molgewicht:
498.92
MOL-Datei:
2380273-75-4.mol

Pomalidomide-PEG3-NH2 hydrochloride Eigenschaften

storage temp. 
2-8°C
Aggregatzustand
Solid
Farbe
White to off-white

Sicherheit

Pomalidomide-PEG3-NH2 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG3-NH2 hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pomalidomide-PEG3-NH2 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 16)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd
+8618235132063
sales@tihondan.com China 3741 58
Xian confluore Biological Technology Co., Ltd.
+86-15680926068 +86-15680926068
1924344760@confluore.cn China 2996 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068
1924344760@qq.com China 4825 58
SuZhou Medinoah Co.,LTD. 0512-69561983 13914027025
zhang_q@medinoah.com China 3605 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624
1927928688@qq.com China 1458 58
Shandong Territorial sea Biological Technology Co., LTD 15092083467
18660263263@163.com China 2425 58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd 15658004993
1900830611@qq.com China 965 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24644 58

  • Pomalidomide-PEG3-NH2 hydrochloride
  • 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide hydrochloride
  • P933620 Pomalidomide-amino-PEG3-NH2 hydrochloride
  • HCl NH2-PEG3-CH2CO-Poma
  • 2380273-75-4
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