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PFI-4

PFI-4 Struktur
900305-37-5
CAS-Nr.
900305-37-5
Englisch Name:
PFI-4
Synonyma:
PFI-4;CS-2035;PFI4;PFI 4;N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide;N-(1,3-Dimethyl-2-oxo-6-pyrrolidin-1-yl-2,3-dihydro-1H-benzimidazol-5-yl)-2-methoxybenzamide;N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide;Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-;N-(1,3-dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide;
N-(1,3-Dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5 -yl)-2-methoxybenzamide;PFI 4,bone loss,Epigenetic Reader Domain,PFI-4,Inhibitor,inhibit,osteoclasts,osteolytic malignant bone lesions
CBNumber:
CB13041445
Summenformel:
C21H24N4O3
Molgewicht:
380.44
MOL-Datei:
900305-37-5.mol

PFI-4 Eigenschaften

Siedepunkt:
512.1±50.0 °C(Predicted)
Dichte
1.291±0.06 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥2.87 mg/mL in EtOH with gentle warming and ultrasonic
pka
12.88±0.20(Predicted)
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

PFI-4 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

PFI-4 is a chemical probe that specifically binds to the bromodomain of BRPF1 inhibiting binding to tri-acetylated histone 4 affecting the development of multiple tissues axial skeleton and hematopoietic system.

Biochem/physiol Actions

PFI-4 is an SGC chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) scaffolding protein BRPF1B. The BRPF proteins (BRPF1/2/3) assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family members MOZ and MORF. The BRPF1 protein is the scaffold subunit of the MYST acetyltransferase complex, which plays a crucial roles in DNA repair, recombination and replication as well as transcription activation. Mutations in MOZ, MORF, and BRPF1 have all been associated with cancer. BRPF1 exists in 2 different isoforms: BRPF1A and BRPF1B. PFI-4 specifically binds to BRPF1B with a Kd =13 nM as determined by ITC. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250nM, while showing no effect on BRPF1A. For full characterization details, please visit the PFI-4 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

PFI-4 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PFI-4 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 71)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30238 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896
cbc@coresyn.com China 9984 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Jilin Chinese Academy of Sciences-yanshen Technology
+undefined18143011203
info@chemextension.com China 42056 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58

  • PFI-4

  • N-(1,3-Dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5 -yl)-2-methoxybenzamide
  • Benzamide, N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxy-
  • N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
  • PFI4;PFI 4
  • CS-2035
  • N-(1,3-Dimethyl-2-oxo-6-pyrrolidin-1-yl-2,3-dihydro-1H-benzimidazol-5-yl)-2-methoxybenzamide
  • N-(1,3-dimethyl-2-oxo-6-pyrrolidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide
  • N-(1,3-dimethyl-2-oxo-6-(pyrrolidin-1-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methoxybenzamide
  • PFI 4,bone loss,Epigenetic Reader Domain,PFI-4,Inhibitor,inhibit,osteoclasts,osteolytic malignant bone lesions
  • 900305-37-5
  • Inhibitors
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