Anti-3-Hydroxy-3-methylglutaryl-CoA reductase Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-HMGCR antibody produced in rabbit has been used in western blotting.
Allgemeine Beschreibung
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) codes for a part of the statin-binding domain of the enzyme. This gene is located on human chromosome 5q13. HMGCR has a molecular mass of 97?kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.
Biochem/physiol Actions
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a major role in mevalonate biosynthesis, which is a rate limiting step of cholesterol biosynthesis in the liver. Additionally, it also plays a key role in various biological process such as, embryogenesis and cancer. Elevated expression of the gene is associated with the development of gastric cancer(GC) and glioblastoma cells. Thus, HMGCR can be considered as a potent therapeutic target for GC and glioblastoma. Polymorphism in HMGCR results in late-onset Alzheimer′s disease.
Anti-3-Hydroxy-3-methylglutaryl-CoA reductase Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
