3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
SR 3576 is a JNK-3 selective inhibitor.
Allgemeine Beschreibung
A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC
50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC
50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 μM. Shown to inhibit streptozotocin- (Cat. No.
572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC
50 = 1.3 μM).
Biochem/physiol Actions
SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1
3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte