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Teneligliptin Hydrobromide

Teneligliptin  Hydrobromide Struktur
906093-29-6
CAS-Nr.
906093-29-6
Englisch Name:
Teneligliptin Hydrobromide
Synonyma:
Teneligliptin HydrobroMide Hydrate;Teneligliptin HBr;3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O;API(Teneligliptin hydro bromide hydrate);3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5);[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide;MP-513 (hydrobromide);Ticagrelor hydrobromide;Tepagliptin (Hydrobromide);Teneligliptin (hydrobroMide)
CBNumber:
CB12666692
Summenformel:
C22H31BrN6OS
Molgewicht:
507.5
MOL-Datei:
906093-29-6.mol

Teneligliptin Hydrobromide Eigenschaften

Schmelzpunkt:
>211°C (dec.)
storage temp. 
Refrigerator
L?slichkeit
Methanol (Slightly)
Aggregatzustand
Solid
Farbe
White to Light Beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H413 Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 4
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Teneligliptin Hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.

Clinical Use

Teneligliptin is a DPP-4 inhibitor which was approved in Japan in 2012 for the treatment of type II diabetes. It was discovered and developed by Mitsubishi Tanabe Pharma under the trade name Tenelia®. Similar to other marketed DPP-4 inhibitors, teneligliptin was well tolerated in all studies and QD dosing produced a long-lasting inhibitory action against DPP-4 and an increase in active GLP-1 levels, with very low rates of renal excretion.

Synthese

The only reported synthesis of teneligliptin is described in the scheme below. Reaction of commercially available N-Boc-piperazine (158) with diketene (159) in DMF at room temperature gave acetoacetamide 160 in 86% yield, and this material was immediately condensed with phenylhydrazine in methanesulfonic acid followed by a cyclodehydration with phosphorus oxychloride to give pyrazole 161 in 12% yield. The t-butyl carbamate was then removed with TFA in dichloromethane to give amine 162 in 88% yield. This amine was then subjected to butyrolactam 165 (which was prepared from N-Boctrans- 4-hydroxy-L-proline (163) coupled with thiazolidine (164) under conventional amide-forming conditions using EDC) in the presence of sodium triacetoxy borohydride (STAB-H) in acetic acid. This reductive amination reaction afforded the cis-aminopyrrolidine 166 exclusively in 50% yield. Removal of the t-butyl carbamate group with TFA afforded the teneligliptin free amine in 93% yield, and this freebase was then subsequently treated with 48% hydrobromic acid in refluxing ethanol to give teleligliptin hydrobromide hydrate (XXV) in 90% yield.

Synthesis_906093-29-6

Teneligliptin Hydrobromide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Teneligliptin Hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 187)Lieferanten
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Hangzhou Hyper Chemicals Limited
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BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
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sales@sjar-tech.com China 456 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
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Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
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Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED
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ivan@atkchemical.com China 32957 60
career henan chemical co
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sales@coreychem.com China 29880 58
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86-13657291602
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BOC Sciences
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inquiry@bocsci.com United States 19553 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 419 58

  • Teneligliptin (hydrobroMide)
  • Teneligliptin HydrobroMide (2:5)
  • MP-513 (hydrobromide)
  • Teneligliptin hydrobromide anhydrous
  • TENELIGLIPTIN HEMIPENTA HYDROBROMIDE HYDRATE
  • ((2S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone
  • 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piper...
  • Teneligliptin hydrobromideQ: What is Teneligliptin hydrobromide Q: What is the CAS Number of Teneligliptin hydrobromide Q: What is the storage condition of Teneligliptin hydrobromide Q: What are the applications of Teneligliptin hydrobromide
  • Teneligliptin Hydrobromide API
  • Teneligliptin HydrobroMide Hydrate
  • 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5)
  • Teneligliptin HBr
  • [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide
  • API(Teneligliptin hydro bromide hydrate)
  • 3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O
  • Teneligliptin(hydrobromide)-amorphous
  • Bis(((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone) pentahydrobromide
  • Methanone, [(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-, hydrobromide (2:5)
  • (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-Methanone hydrobromide (2:5)
  • Ticagrelor hydrobromide
  • Teneligliptin HBr [(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]- 2-pyrrolidinyl]-3-thiazolidinylmethanone HBr
  • Tepagliptin (Hydrobromide)
  • 906093-29-6
  • 2C22H30N6OS5HBr
  • C44H65Br5N12O2S2
  • 2C22H30N6OS5BrH
  • API
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