DWK-1339
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- CAS-Nr.
- 1018946-38-7
- Englisch Name:
- DWK-1339
- Synonyma:
- SNU-0039;DWK-1339;SNU-0039 (DWK-133);DWK-1339;DWK 1339;DWK1339;2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-1-benzofuran;Benzofuran, 2-(3,4-diMethoxyphenyl)-5-(3-Methoxypropyl)-;2-(3,4-DiMethoxy-phenyl)-5-(3-Methoxy-propyl)-benzofuran;MDR1339,DWK1339,inhibit,β-amyloid peptide,Inhibitor,MDR 1339,Abeta,Amyloid-β,MDR-1339,DWK 1339
- CBNumber:
- CB12627783
- Summenformel:
- C20H22O4
- Molgewicht:
- 326.39
- MOL-Datei:
- 1018946-38-7.mol
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DWK-1339 Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- DMF: 30mg/mL; DMSO: 30mg/mL; Ethanol: 2mg/mL
- Aggregatzustand
- A crystalline solid
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
DWK-1339 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
DWK-1339 is an inhibitor of amyloid-β (Aβ) aggregation. It inhibits aggregation of monomeric Aβ (1-42) (Aβ42) and induces disaggregation of Aβ42 fibrils
in vitro when used at concentrations ranging from 3.1 to 50 μM. DWK-1339 (10 μM) reduces Aβ42-induced toxicity in HT-22 cells.
In vivo, DWK-1339 (10 mg/kg) increases step-through latency in a passive avoidance test and increases spontaneous alteration in the Y-maze compared with vehicle control mice in a mouse model of Aβ42-induced acute Alzheimer''s disease. It also decreases brain levels of Aβ42 and increases spontaneous alteration in the Y-maze in the APP/PS1 transgenic mouse model of Alzheimer''s disease.
Verwenden
DWK-1339, is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer''s disease.
DWK-1339 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DWK-1339 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 33)Lieferanten
- DWK-1339
- 2-(3,4-DiMethoxy-phenyl)-5-(3-Methoxy-propyl)-benzofuran
- Benzofuran, 2-(3,4-diMethoxyphenyl)-5-(3-Methoxypropyl)-
- 2-(3,4-dimethoxyphenyl)-5-(3-methoxypropyl)-1-benzofuran
- DWK-1339;DWK 1339;DWK1339
- SNU-0039
- SNU-0039 (DWK-133)
- MDR1339,DWK1339,inhibit,β-amyloid peptide,Inhibitor,MDR 1339,Abeta,Amyloid-β,MDR-1339,DWK 1339
- 1018946-38-7
- 1018964-38-7
