PeraMpanel
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- CAS-Nr.
- 380917-97-5
- Englisch Name:
- PeraMpanel
- Synonyma:
- Perampane;PeraMpanel-D5;PERAMPANEL API;Perampanel Impurity;3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one;2-(2-oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile;E 2007;CS-1116;PeraMpanel;Pyronoprene
- CBNumber:
- CB12598797
- Summenformel:
- C23H15N3O
- Molgewicht:
- 349.38
- MOL-Datei:
- 380917-97-5.mol
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PeraMpanel Eigenschaften
- Siedepunkt:
- 619.1±55.0 °C(Predicted)
- Dichte
- 1.31±0.1 g/cm3(Predicted)
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- Powder
- pka
- 4.73±0.19(Predicted)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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Sicherheit |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
P330 |
Mund ausspülen. |
P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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PeraMpanel Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In October 2012, the US FDA approved perampanel for the treatment of partial onset seizures in epileptic patients who are at least 12 years old. Perampanel is the first AMPA receptor antagonist to receive FDA approval as an AED. AMPA glutamate receptors are found primarily on postsynaptic neurons in the brain. As a selective, noncompetitive antagonist of AMPA, parampanel prevents ion channel opening and reduces propagation of action potential. Parampanel was discovered through lead optimization of a commercially available compound, 2,4-diphenyl-4H-[1,3,4]oxadiazin-5-one, which was identified by high-throughput screening of a compound collection employing a rat cortical neuron AMPA-induced cell-death assay. Modifications of aromatic rings at positions 1, 3, and 5 while changing the core to pyridone led to parampanel which inhibited AMPA-induced calcium influx (IC
50=60 nM). Parampanel had a minimum effective oral dose of 2 mg/kg in an AMPA-induced mouse seizure model. The synthesis of parampanel was accomplished via a 6-step route utilizing Suzuki–Miyaura couplings and modified Ullmann reactions for incorporation of aryl groups.
Verwenden
Isotope labelled Perampanel (P285520), is an antiepileptic drug. It inhibits α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-induced increases in intracellular Ca2+ and selectively blocks AMPA receptor-mediated synaptic transmission, thus reducing neuronal excitation.
Definition
ChEBI: A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.
PeraMpanel Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
380917-97-5()Verwandte Suche:
- 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
- 2-(6'-Oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile
- Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-
- ER 155055-90 Perampanel
- 2-(2-oxo-1-phenyl-5-pyridin-2-
ylpyridin-3-yl)benzonitrile
- Perampane,Perampanel
Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)
- PeraMpanel
- E 2007
- ER 155055-90
- PeraMpanel-13C6
- CS-1116
- E 2007; ER 155055-90; E-2007; E2007
- Perampanel(E2007)
- Perampanel/D3-labelled (3R,4R)-1-Benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride
- Perampanel Impurity 8
- Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyrid...
- 3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one
- 2-(2-oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile
- Perampane
- PeraMpanel-D5
- PERAMPANEL API
- Perampanel Impurity
- Pyronoprene
- 2-(6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile
- Perampanel D5 Impurity
- 380917-97-5
- 543669-60-1
- 380919-54-7
- C1713C6H15N3O
- Inhibitors
- API