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3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Struktur
1014691-61-2
CAS-Nr.
1014691-61-2
Englisch Name:
3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester
Synonyma:
CS-738;GSK 0660;GSK-0660, >=98%;GSK-0660 (GSK0660);GSK0660 >=98% (HPLC);GSK-0660;GSK 0660;GSK0660;4-Chloro-3-iodo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine;METHYL 3-[(4-ANILINO-2-METHOXYPHENYL)SULFAMOYL]THIOPHENE-2-CARBOXYLATE;methyl 3-{[2-methoxy-4-(phenylamino)phenyl]sulfamoyl}thiophene-2-carboxylate;Methyl 3-(N-(2-Methoxy-4-(phenylaMino)phenyl)sulfaMoyl)thiophene-2-carboxylate
CBNumber:
CB12518768
Summenformel:
C19H18N2O5S2
Molgewicht:
418.49
MOL-Datei:
1014691-61-2.mol

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Eigenschaften

Siedepunkt:
608.1±65.0 °C(Predicted)
Dichte
1.413±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble10mg/mL, clear
Aggregatzustand
powder
pka
8.51±0.50(Predicted)
Farbe
white to beige
InChIKey
NDFKBGWLUHKMFY-UHFFFAOYSA-N

Sicherheit

WGK Germany  2

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

GSK0660 has been used to study the effects of bezafibrate (BZA) on hypertrophy.

Allgemeine Beschreibung

GSK0660 has antiangiogenic property in oxygen-induced retinopathy. It also regulates tumor necrosis factor-α (TNFα)-induced inflammation in human retinal microvascular endothelial cells (HRMECs).

Biochem/physiol Actions

GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (160 nM). GSK0660 is nearly inactive on PPARα and PPARγ with IC50s greater than 10 μM.

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 97)Lieferanten
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181
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Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
  • GSK-0660, >=98%
  • 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester
  • GSK 0660
  • Methyl 3-(N-(2-Methoxy-4-(phenylaMino)phenyl)sulfaMoyl)thiophene-2-carboxylate
  • 2-Thiophenecarboxylic acid, 3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-, methyl ester
  • 4-Chloro-3-iodo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
  • METHYL 3-[(4-ANILINO-2-METHOXYPHENYL)SULFAMOYL]THIOPHENE-2-CARBOXYLATE
  • 3-(2-Methoxy-4-phenylamino-phenylsulfamoyl)-thiophene-2-carboxylic acid methyl ester
  • CS-738
  • GSK-0660 (GSK0660)
  • GSK-0660;GSK 0660;GSK0660
  • GSK0660 >=98% (HPLC)
  • methyl 3-{[2-methoxy-4-(phenylamino)phenyl]sulfamoyl}thiophene-2-carboxylate
  • 1014691-61-2
  • Inhibitors
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