Mitoxantrone Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R46:Kann vererbbare Sch?den verursachen.
R61:Kann das Kind im Mutterleib sch?digen.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
Chemische Eigenschaften
Dark Blue Crystalline Solid
Verwenden
Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.
Indications
Mitoxantrone (Novantrone) is a synthetic anthraquinone
that is structurally and mechanistically related to the anthracyclines.
It intercalates with DNA and produces single-
strand DNA breakage. It is cross-resistant with doxorubicin
in multidrug-resistant cells and in patients who
have failed to respond to doxorubicin therapy.
Mitoxantrone is active against breast carcinomas,
leukemias, and lymphomas. Its antitumor efficacy in patients
with breast cancer is slightly lower than that of
doxorubicin. Its major toxicity is myelosuppression; mucositis
and diarrhea also may occur. Mitoxantrone produces
less nausea, alopecia, and cardiac toxicity than
does doxorubicin.
Mechanism of action
The mechanism of its action is not completely understood, although it is presumed, that
mitoxantrone acts by binding with DNA, thus disturbing the twisting process of the chains.
It is used intravenously for treating severe nonlymphatic leukemia, breast cancer, and so
on. A synonym of this drug is novantrone.
Mitoxantrone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
